Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity

doi:10.1007/s11164-018-3503-0

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity
	Jiang, Jing 3; Qiu, Jie 1; Lou, Liguang2 ; Gao, Anli 3; Hou, Shuqian 3; Liu, Weiping 3
刊名	RESEARCH ON CHEMICAL INTERMEDIATES
	2018-11
卷号	44 期号:11 页码:6479-6487
关键词	Platinum(II) complexes Anticancer activity 3-OH-cyclobutane-1 1-dicarboxylate Mixed-NH3/RNH2 Non-coordination planer cis- trans-isomerism
ISSN号	0922-6168
DOI	10.1007/s11164-018-3503-0
文献子类	Article
英文摘要	Two isomers of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)] (R=cycopentyl, cyclohexyl) were separated, structurally characterized and tested for their anticancer activity. X-ray structural analysis revealed that this isomerism originates from two opposite spatial orientations of the hydroxyl group on the cyclobutane ring in relation to the coordinated NH3, resulting in cis- and trans-configurations. The two isomers have approximately equal anticancer activity, probably due to a relatively long distance between the hydroxyl group and the Pt(II) coordination plane. Therefore, the separation of such isomers is not recommended during drug development.
资助项目	Natural Science Foundation of China[21661018] ; Yunnan Provincial R&D Project of China[2014BC010] ; Yunnan Provincial R&D Project of China[2017ZF010]
WOS关键词	CANCER-CHEMOTHERAPY ; PLATINUM COMPLEXES ; ANTITUMOR-ACTIVITY ; AGENTS ; DRUGS ; DELIVERY ; HISTORY ; FUTURE ; ANALOG
WOS研究方向	Chemistry
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000449307900003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279513]
专题	药理学第一研究室
通讯作者	Liu, Weiping
作者单位	1.Lincan Maternal & Child Hlth Care Hosp, Kaiyuan, Yunnan, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Kunming Inst Precious Met, State Key Lab Platinum Grp Met, Kunming, Yunnan, Peoples R China;
推荐引用方式 GB/T 7714	Jiang, Jing,Qiu, Jie,Lou, Liguang,et al. Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity[J]. RESEARCH ON CHEMICAL INTERMEDIATES,2018,44(11):6479-6487.
APA	Jiang, Jing,Qiu, Jie,Lou, Liguang,Gao, Anli,Hou, Shuqian,&Liu, Weiping.(2018).Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity.RESEARCH ON CHEMICAL INTERMEDIATES,44(11),6479-6487.
MLA	Jiang, Jing,et al."Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity".RESEARCH ON CHEMICAL INTERMEDIATES 44.11(2018):6479-6487.