Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)

doi:10.1021/jf202544w

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)
	Feng, Tao 1; Su, Jia 1; Ding, Zhi-Hui 1; Zheng, Yong-Tang 3,4; Li, Yan 1; Leng, Ying2 ; Liu, Ji-Kai 1
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2011-11-09
卷号	59 期号:21 页码:11690-11695
关键词	Zingiber officinale Tongling White Ginger gingerdione dimers gingerol derivatives 11 beta-HSD
ISSN号	0021-8561
DOI	10.1021/jf202544w
文献子类	Article
英文摘要	Gingerols and their corresponding dehydration products shogaols were considered as the active principles of ginger, the rhizome of the plant Zingiber officinale, for its antioxidant, ant-inflammatory, and antitumor activities Ginger (Z. officinale) has been cultivated for thousands of years as a spice and for medicinal purposes in China. Tongling (Anhui province, China) has traditionally been regarded as an ideal cultivation place "Tongling White Ginger" enjoys a reputation for being one of the top gingers in China for its thin white peel, tender flesh, rich juice, and flavor In this study, we have isolated and identified two novel gingerdione dimers, bisgingerdiones A (1) and B (2), two new gingerol derivatives, (5R)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (3) and methyl (Z)-neral acetal-[6]-gingerdiol (4), and 38 known compounds (5-42) from rhizomes of Zingiber officinale collected from Tongling, China. Their structures were elucidated by means of spectroscopic methods Compounds 1-4 showed weak cytotoxic and anti-HIV-1 activities Compounds 6, 8, and 26 showed inhibitory activities against human and mouse 11 beta-HSD1 (11 beta-hydroxysteroid dehydrogenases) with IC50 values between 1 09 and 1 30 mu M.
资助项目	National Basic Research Program of China (973 Program)[2009CB522300] ; National Natural Sciences Foundation of China[30830113] ; MOST[2009ZX09501-029]
WOS关键词	DIARYLHEPTANOIDS ; PROLIFERATION ; RHIZOMES ; CELLS
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000296312000041
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278338]
专题	药理学第一研究室
通讯作者	Liu, Ji-Kai
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China; 4.Chinese Acad Sci, Kunming Inst Bot, Lab Mol Immunopharmacol, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Feng, Tao,Su, Jia,Ding, Zhi-Hui,et al. Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011,59(21):11690-11695.
APA	Feng, Tao.,Su, Jia.,Ding, Zhi-Hui.,Zheng, Yong-Tang.,Li, Yan.,...&Liu, Ji-Kai.(2011).Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,59(21),11690-11695.
MLA	Feng, Tao,et al."Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 59.21(2011):11690-11695.