3-Hydroxycarboplatin, a Simple Carboplatin Derivative Endowed with an Improved Toxicological Profile

doi:10.1595/147106712X654204

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	3-Hydroxycarboplatin, a Simple Carboplatin Derivative Endowed with an Improved Toxicological Profile
	Liu, Weiping 1; Chen, Xizhu 1; Ye, Qingsong 1; Hou, Shuqian 1; Lou, Liguang2 ; Xie, Chengying2
刊名	PLATINUM METALS REVIEW
	2012-10
卷号	56 期号:4 页码:248-256
ISSN号	0032-1400
DOI	10.1595/147106712X654204
文献子类	Article
英文摘要	3-Hydroxycarboplatin, a simple carboplatin derivative, was synthesised using a novel method, characterised and evaluated for its anticancer activity in vitro and in vivo. It shows comparable antitumour activity to that of carboplatin but has much lower toxicity particularly with respect to myelosuppression, revealing great potential for development as a new antitumour platinum drug to replace carboplatin.
资助项目	National Science Foundation of P. R. China[21161010] ; China National Research and Development (RD) Program[2012BAE06B08]
WOS关键词	PLATINUM(II) COMPLEXES ; SALICYLATE DERIVATIVES ; ANTICANCER ACTIVITY ; ANTITUMOR-ACTIVITY ; CANCER ; ANALOG
WOS研究方向	Chemistry
语种	英语
出版者	JOHNSON MATTHEY PUBL LTD CO
WOS记录号	WOS:000313558800006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277914]
专题	药理学第一研究室
通讯作者	Liu, Weiping
作者单位	1.Kunming Inst Precious Met, State Key Lab Adv Technol Comprehens Utilizat Pla, Kunming 650106, Yunnan, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Liu, Weiping,Chen, Xizhu,Ye, Qingsong,et al. 3-Hydroxycarboplatin, a Simple Carboplatin Derivative Endowed with an Improved Toxicological Profile[J]. PLATINUM METALS REVIEW,2012,56(4):248-256.
APA	Liu, Weiping,Chen, Xizhu,Ye, Qingsong,Hou, Shuqian,Lou, Liguang,&Xie, Chengying.(2012).3-Hydroxycarboplatin, a Simple Carboplatin Derivative Endowed with an Improved Toxicological Profile.PLATINUM METALS REVIEW,56(4),248-256.
MLA	Liu, Weiping,et al."3-Hydroxycarboplatin, a Simple Carboplatin Derivative Endowed with an Improved Toxicological Profile".PLATINUM METALS REVIEW 56.4(2012):248-256.