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	Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin
	Jiang Jing1; Lou Li-Guang2; Chen Xi-Zhu1; Xu Yong-Ping2; Ye Qing-Song1; Liu Wei-Ping1
刊名	CHINESE JOURNAL OF INORGANIC CHEMISTRY
	2014-02-10
卷号	30期号:2页码:317-322
关键词	platinum complexes synthesis anti-tumor
ISSN号	1001-4861
文献子类	Article
英文摘要	Two water-soluble derivatives of heptaplatin, cis-[(4R,5R)-4,5-bis (aminomethyl)-2-R-1,3-dioxolane](3-hydroxy-1,1-cyclobutanedicarboxylato) platinum(II) (R=ethyl and methyl), were synthesized and characterized by elemental analysis, FAB(+)-MS and FT-IR along with C-13 NMR. They were evaluated for the cytotoxicity against three human cancer cell lines and for the antitumor activity in the murine S180 model. The results show that despite their cytotoxic potency slightly lower than that of heptaplatin, the derivatives exhibits higher antitumor activity and are worthy of further research.
WOS关键词	PLATINUM(II) COMPLEXES ; CANCER ; TOXICITY ; AGENTS ; DRUGS
WOS研究方向	Chemistry
语种	中文
CSCD记录号	CSCD:5059523
出版者	CHINESE CHEMICAL SOC
WOS记录号	WOS:000332434100013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277188]
专题	药理学第一研究室
通讯作者	Liu Wei-Ping
作者单位	1.Kunming Inst Precious Met, State Key Lab Platinum Grp Met, Kunming 650106, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Jiang Jing,Lou Li-Guang,Chen Xi-Zhu,et al. Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2014,30(2):317-322.
APA	Jiang Jing,Lou Li-Guang,Chen Xi-Zhu,Xu Yong-Ping,Ye Qing-Song,&Liu Wei-Ping.(2014).Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin.CHINESE JOURNAL OF INORGANIC CHEMISTRY,30(2),317-322.
MLA	Jiang Jing,et al."Synthesis and Anti-Tumor Activity of Two New Water-Soluble Derivatives of Heptaplatin".CHINESE JOURNAL OF INORGANIC CHEMISTRY 30.2(2014):317-322.

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