The role of microRNA in Alzheimer's disease

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	The role of microRNA in Alzheimer's disease
	He Xiang 2; Wang Tao 1; Du Xiaoguang 2; Xiao Shifu 1; Geng Meiyu2
刊名	Chinese Bulletin of Life Sciences
	2015
卷号	27 期号:5 页码:569-573
关键词	Alzheimers disease microRNA pathogenesis
ISSN号	1004-0374
其他题名	MicroRNA在阿尔兹海默病中的作用研究
文献子类	Review
英文摘要	Alzheimers disease (AD) is a complex neurodegenerative disorder and also the most common dementia among the elderly. Accumulating data indicate that microRNAs (miRNAs) are involved in the development of AD. MiRNAs (~22 nt) are non-coding single strand RNA molecules and interact with complementary mRNA sequences in the UTR of genes to result in either translational repression or degradation of the targets. MiRNAs are important in neural development and function. Here, we review current findings regarding the potential contribution of miRNA in the pathogenesis of AD.The relationship between miRNA and APP, BACE1, tau, inflammation and neruo apoptosis are focused on.
资助项目	国家自然科学基金青年基金项目[00000000]
WOS研究方向	Biochemistry & Molecular Biology ; General & Internal Medicine ; Neurosciences & Neurology (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5455574
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269279]
专题	药理学第一研究室药物安全性评价中心
通讯作者	Geng Meiyu
作者单位	1.Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China. 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;
推荐引用方式 GB/T 7714	He Xiang,Wang Tao,Du Xiaoguang,et al. The role of microRNA in Alzheimer's disease[J]. Chinese Bulletin of Life Sciences,2015,27(5):569-573.
APA	He Xiang,Wang Tao,Du Xiaoguang,Xiao Shifu,&Geng Meiyu.(2015).The role of microRNA in Alzheimer's disease.Chinese Bulletin of Life Sciences,27(5),569-573.
MLA	He Xiang,et al."The role of microRNA in Alzheimer's disease".Chinese Bulletin of Life Sciences 27.5(2015):569-573.