Effects of autologous intracoronary bone marrow mononuclear cell transplantation on cardiac function in adriamycin-induced cardiomyopathic rabbits

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	Effects of autologous intracoronary bone marrow mononuclear cell transplantation on cardiac function in adriamycin-induced cardiomyopathic rabbits
	Jin B(金波)1; Shi HM(施海明)1; Li J(李剑)1; Li Y(李勇)1; Luo XP(罗心平)1; Wang YP(王逸平)2 ; Sun WK(孙伟康)2; Zhu J(朱军)1; Huang CL(黄成磊)1; Shen W(沈伟)1
刊名	Shanghai Medical Journal
	2008
卷号	31 期号:5 页码:328
关键词	Cardiomyopathy Matrix remodeling Metalloproteinase New Zealand rabbits Cell transplantation
ISSN号	0253-9934
其他题名	经冠状动脉自体骨髓单个核细胞移植对阿霉素心肌病兔心功能的影响
文献子类	Article
英文摘要	Objective To establish a new animal model of autologous intracoronary bone marrow mononu- clear cells(BMMNCs)transplantation in adriamycin-induced dilated cardiomyopathic(DCM)rabbits and evaluate the cardiac matrix remodeling after transplantation,in an attempt to explore the relationship between cardiac re- modeling and the improvement of cardiac function.Methods Adriamycin was injected through ear-border vein to produce DCM model with male New Zealand rabbits.Twenty survived DCM rabbits were equally randomized into intracoronary transplant group and control group.Autologous BMMNCs were infused into the left coronary artery in the intracoronary transplant group through plastic 4F catheter.The collagen volume fraction(CVF), matrix metalloproteinase(MMP)-2 and MMP-3 in the left ventricular myocardium were semi-quantitative deter- mined to evaluate the cardiac matrix remodeling;indices of hemodynamics and rabbit serum brain natriuretic peptide(BNP)concentration were measured for evaluation of the cardiac function.Results Four weeks later, BMMNCs transplantation significantly improved the cardiac function and decreased the expression of MMP-2 and MMP-3 in the myocardium;the CVF increased by(0.971.94)% in the transplantation group and by(11.582.82)% in the control group.The serum BNP level decreased from(172.1615.28)mug/L to(128.4610.02)mug/L in the transplant group(P<0.01).Conclusion Autologous intracoronary transplantation of BMMNCs in DCM rabbits can delay the progress of collagen metabolism during cardiac matrix remodeling,which might be related to the inhibition of stress-associated MMPs changes and delay of the collagen metabolism during cardiac matrix remode- ling,subsequently resulting in the improvement of cardiac function.
资助项目	上海市卫生局科技发展基金资助项目(054065)[00000000]
WOS研究方向	General & Internal Medicine (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:3306126
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268032]
专题	药理学第一研究室
作者单位	1.复旦大学附属华山医院心内科, 上海 200040, 中国.; 2.中科院上海药物研究所.
推荐引用方式 GB/T 7714	Jin B,Shi HM,Li J,et al. Effects of autologous intracoronary bone marrow mononuclear cell transplantation on cardiac function in adriamycin-induced cardiomyopathic rabbits[J]. Shanghai Medical Journal,2008,31(5):328.
APA	金波.,施海明.,李剑.,李勇.,罗心平.,...&沈伟.(2008).Effects of autologous intracoronary bone marrow mononuclear cell transplantation on cardiac function in adriamycin-induced cardiomyopathic rabbits.Shanghai Medical Journal,31(5),328.
MLA	金波,et al."Effects of autologous intracoronary bone marrow mononuclear cell transplantation on cardiac function in adriamycin-induced cardiomyopathic rabbits".Shanghai Medical Journal 31.5(2008):328.