Repair pathways in response to DNA double-strand breaks

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	Repair pathways in response to DNA double-strand breaks
	Huang, Min; Miao, Ze-Hong; Ding, Jian
	2007-10
卷号	38
期号	4
页码	295-300
英文摘要	DNA double-strand breaks (DSBs) are the principal cytotoxic lesions caused by many exogenous and endogenous factors. In response to DSBs, cells have evolved complex and highly conserved systems, which mainly consist of homologous recombination repair (HR) and non-homologous end joining (NHEJ) pathways, to effectively repair the lethal lesions. The two pathways play crucial roles in preserving the genomic integrity. Here, we provide an overview of detailed process, concerned molecules and regulatory factors in these pathways. Accumulated knowledge of DSBs repair may offer opportunities to develop more effective treatments for cancer.
会议录	Sheng li ke xue jin zhan [Progress in physiology]
文献子类	Meeting Abstract;Article;Review
语种	中文
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266887]
专题	药理学第一研究室
作者单位	Divisn of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
推荐引用方式 GB/T 7714	Huang, Min,Miao, Ze-Hong,Ding, Jian. Repair pathways in response to DNA double-strand breaks[C]. 见:.