Rhodium(III)-Catalyzed C-H Activation of alpha-Iminonitriles or alpha-Imino Esters and Cyclization with Acrylates to 2H-Isoindoles

doi:10.1021/acs.joc.8b01664

	Rhodium(III)-Catalyzed C-H Activation of alpha-Iminonitriles or alpha-Imino Esters and Cyclization with Acrylates to 2H-Isoindoles
	Li, Yazhou 1; Zhou, Jianhui 2; Fang, Feifei 2; Xu, Bin1 ; Liu, Hong2 ; Zhou, Yu2
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2018-10-05
卷号	83 期号:19 页码:11736-11746
ISSN号	0022-3263
DOI	10.1021/acs.joc.8b01664
文献子类	Article
英文摘要	Rh(III) catalysts have played increasingly important roles in the activation of C-H bonds to build heterocyclic scaffolds. However, there are few reports on the more challenging synthesis of pharmaceutically important 2H-isoindoles and fused 2H-isoindoles. The process reported herein is an effective strategy to produce 2H-isoindole or fused 2H-isoindole derivatives via a Rh(III)-catalyzed transformation of alpha-iminonitriles or alpha-imino esters with acrylates.
资助项目	National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81620108027]
WOS关键词	BOND ACTIVATION ; ANTIPROLIFERATIVE ACTIVITY ; SELECTIVE HYDROARYLATION ; PROPARGYL ALCOHOLS ; DIVERSE SYNTHESIS ; DIAZO-COMPOUNDS ; ANNULATION ; DERIVATIVES ; ISOINDOLES ; FUNCTIONALIZATION
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000447118100025
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279540]
专题	药物化学研究室药理学第一研究室
通讯作者	Liu, Hong; Zhou, Yu
作者单位	1.Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Yazhou,Zhou, Jianhui,Fang, Feifei,et al. Rhodium(III)-Catalyzed C-H Activation of alpha-Iminonitriles or alpha-Imino Esters and Cyclization with Acrylates to 2H-Isoindoles[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(19):11736-11746.
APA	Li, Yazhou,Zhou, Jianhui,Fang, Feifei,Xu, Bin,Liu, Hong,&Zhou, Yu.(2018).Rhodium(III)-Catalyzed C-H Activation of alpha-Iminonitriles or alpha-Imino Esters and Cyclization with Acrylates to 2H-Isoindoles.JOURNAL OF ORGANIC CHEMISTRY,83(19),11736-11746.
MLA	Li, Yazhou,et al."Rhodium(III)-Catalyzed C-H Activation of alpha-Iminonitriles or alpha-Imino Esters and Cyclization with Acrylates to 2H-Isoindoles".JOURNAL OF ORGANIC CHEMISTRY 83.19(2018):11736-11746.