A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from alpha-hydroxyesters using trichloroacetyl isocyanate

doi:10.1016/j.tetlet.2008.11.124

	A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from alpha-hydroxyesters using trichloroacetyl isocyanate
	Li, Yue H.1; Zhang, Li 3; Tseng, Pei-San 2; Zhang, Yongliang 3; Jin, Yu 3; Shen, Jingkang 3; Jin, Jian 2
刊名	TETRAHEDRON LETTERS
	2009-02-18
卷号	50 期号:7 页码:790-792
关键词	3-Unsubstituted-2,4-oxazolidinedione Trichloroacetyl isocyanate alpha-Hydroxyester Carbamate
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2008.11.124
文献子类	Article
英文摘要	A convenient, high yield one-pot methodology for the synthesis of pharmaceutically interesting 3-unsubstituted-2,4-oxazolidinediones from alpha-hydroxyesters is described. A primary carbamate was generated in situ from the corresponding alpha-hydroxyester and trichloroacetyl isocyanate, then converted to the desired 3-unsubstituted 2,4-oxazolidinedione via intramolecular ring closure. This method is amenable to scale-up and requires no chromatographic purification. (C) 2008 Elsevier Ltd. All rights reserved.
WOS关键词	DERIVATIVES
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000263319900015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279310]
专题	药物化学研究室
通讯作者	Li, Yue H.
作者单位	1.GlaxoSmithKline Inc, Discovery Med Chem, Collegeville, PA 19426 USA; 2.GlaxoSmithKline Inc, Cardiovasc & Urogenital CEDD, King Of Prussia, PA 19406 USA; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Discovery, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Yue H.,Zhang, Li,Tseng, Pei-San,et al. A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from alpha-hydroxyesters using trichloroacetyl isocyanate[J]. TETRAHEDRON LETTERS,2009,50(7):790-792.
APA	Li, Yue H..,Zhang, Li.,Tseng, Pei-San.,Zhang, Yongliang.,Jin, Yu.,...&Jin, Jian.(2009).A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from alpha-hydroxyesters using trichloroacetyl isocyanate.TETRAHEDRON LETTERS,50(7),790-792.
MLA	Li, Yue H.,et al."A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from alpha-hydroxyesters using trichloroacetyl isocyanate".TETRAHEDRON LETTERS 50.7(2009):790-792.