Structural Diversity and Structure-Activity Relationship-New Drug Research and Development of Tripterygium wilfordii Hook. f.

	Structural Diversity and Structure-Activity Relationship-New Drug Research and Development of Tripterygium wilfordii Hook. f.
	Li Zheng; Li Yuanchao
刊名	PROGRESS IN CHEMISTRY
	2009-12
卷号	21 期号:12 页码:2483-2491
关键词	triptolide structure modification structure-activity relationship (SAR)
ISSN号	1005-281X
文献子类	Article
英文摘要	Tripterygium wilfordii Hook. f. (TWHF alpha), commonly known as Lei Gong Teng (Thunder God Vine), is a vine used in traditional Chinese herbal medicine. Triptolide, the major component responsible for the clinical properties of TWHF, is characterized as an abeo-abietane-typed diterpenoid with a unique triepoxide structure and alpha, beta-unsaturated-5-membered lactone. Right after its isolation, triptolide is shown to possess a broad spectrum of pharmacological activities including anticancer, anti-fertility besides its remarkable anti-inflammatory and immunosuppressive activities, which led to extensive studies. Through the modification of different functional groups in triptolide, including the C14-hydroxyl group, C12 beta, C13 beta-epoxy group, alpha, beta-unsaturated-5-membered-lactone ring, C7 beta, C8 beta-epoxy group, C5, C6- position, and three epoxy ring-opening transformation etc., a series of derivatives are synthesized and their related pharmacological activities are tested. Some preliminary structure-activity relationship (SAR) characteristics are summarized from the pharmacological test results. With the accumulation and deepening of chemical and biological study of 1, its SAR will be clearer. Low toxicity, high activity, and wide therapeutic window derivatives of 1 will definitely make 1 a broad application prospect in many fields.
WOS关键词	TRIPTOLIDE ; ANALOGS
WOS研究方向	Chemistry
语种	中文
CSCD记录号	CSCD:3774071
出版者	CHINESE ACAD SCIENCES
WOS记录号	WOS:000273314100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279080]
专题	药物化学研究室
通讯作者	Li Yuanchao
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li Zheng,Li Yuanchao. Structural Diversity and Structure-Activity Relationship-New Drug Research and Development of Tripterygium wilfordii Hook. f.[J]. PROGRESS IN CHEMISTRY,2009,21(12):2483-2491.
APA	Li Zheng,&Li Yuanchao.(2009).Structural Diversity and Structure-Activity Relationship-New Drug Research and Development of Tripterygium wilfordii Hook. f..PROGRESS IN CHEMISTRY,21(12),2483-2491.
MLA	Li Zheng,et al."Structural Diversity and Structure-Activity Relationship-New Drug Research and Development of Tripterygium wilfordii Hook. f.".PROGRESS IN CHEMISTRY 21.12(2009):2483-2491.