Dodoviscin A Inhibits Melanogenesis in Mouse B16-F10 Melanoma Cells

doi:10.1055/s-0032-1328649

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	Dodoviscin A Inhibits Melanogenesis in Mouse B16-F10 Melanoma Cells
	Yan, Guirui 1; Zhu, Jingjie 1; Zhang, Laibin 2; Xu, Zhijian1 ; Wang, Gaihong 1; Zhu, Weiliang1 ; Hou, Aijun 2; Wang, Heyao1
刊名	PLANTA MEDICA
	2013-07
卷号	79 期号:11 页码:933-938
关键词	dodoviscin A Dodonaea viscosa Sapindaceae melanogenesis tyrosinase CREB
ISSN号	0032-0943
DOI	10.1055/s-0032-1328649
文献子类	Article
英文摘要	Nowadays, abnormal hyperpigmentation in human skin such as melasma, freckles, and chloasma has become a serious esthetic problem. Cutaneous depigmenting agents could be used to treat these hyperpigmentation-associated dieseases. Dodoviscin A is a natural product isolated from the aerial parts of Dodonaea viscosa. In the present study, we evaluated the effect of dodoviscin A on melanin production in B16-F10 melanoma cells for the first time. We found that dodoviscin A inhibited melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059 significantly, and there was no obvious effect on the viability of dodoviscin A-treated B16-F10 cells. Meanwhile, dodoviscin A could suppress the activity of mushroom tyrosinase in the cell-free assay system and also decrease 3-isobutyl-1-methylxanthine-induced tyrosinase activity and expression of mature tyrosinase protein in B16-F10 cells. Western blotting analysis showed that dodoviscin A inhibited 3-isobutyl-1-methylxanthine and forskolin-induced phosphorylation of the cAMP response element binding protein in B16-F10 cells. These results indicate that dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications.
资助项目	National Natural Science Foundation of China[81072681] ; National Marine "863'' Project[2011AA09070102] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001]
WOS关键词	NORMAL HUMAN MELANOCYTES ; ALDER-TYPE ADDUCTS ; DODONAEA-VISCOSA ; TYROSINASE INHIBITORS ; SKIN PIGMENTATION ; CYCLIC-AMP ; BIOSYNTHESIS ; CONSTITUENTS ; ANTIOXIDANT ; MECHANISM
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000330723700005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277543]
专题	药理学第三研究室
通讯作者	Wang, Heyao
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China
推荐引用方式 GB/T 7714	Yan, Guirui,Zhu, Jingjie,Zhang, Laibin,et al. Dodoviscin A Inhibits Melanogenesis in Mouse B16-F10 Melanoma Cells[J]. PLANTA MEDICA,2013,79(11):933-938.
APA	Yan, Guirui.,Zhu, Jingjie.,Zhang, Laibin.,Xu, Zhijian.,Wang, Gaihong.,...&Wang, Heyao.(2013).Dodoviscin A Inhibits Melanogenesis in Mouse B16-F10 Melanoma Cells.PLANTA MEDICA,79(11),933-938.
MLA	Yan, Guirui,et al."Dodoviscin A Inhibits Melanogenesis in Mouse B16-F10 Melanoma Cells".PLANTA MEDICA 79.11(2013):933-938.