Synthesis of Pyrazolo[1,2-a] cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach

doi:10.1002/adsc.201301009

	Synthesis of Pyrazolo[1,2-a] cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach
	Xing, Li 2; Fan, Zhoulong 1,3; Hou, Chengyu 2; Yong, Guoping 2; Zhang, Ao1,3
刊名	ADVANCED SYNTHESIS & CATALYSIS
	2014-03-24
卷号	356 期号:5 页码:972-976
关键词	alkynes oxidative coupling pyrazolo[1 2-a]cinnolines pyrazolones rhodium
ISSN号	1615-4150
DOI	10.1002/adsc.201301009
文献子类	Article
英文摘要	An efficient synthetic strategy for the unique class of pyrazolo[1,2-a]cinnolines was developed through a rhodium-catalyzed oxidative coupling of N-aryl-1H-pyrazol-5(4H)-ones with internal alkynes. This protocol features use of the pyrazolone function in the substrate as an intrinsic directing group, hexafluoroisopropyl alcohol (HFIP) as the solvent, and mild reaction conditions as well as a wide substrate scope.
资助项目	Chinese National Sciences Foundation[81125021] ; Chinese National Sciences Foundation[81373277] ; National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program, China[2012ZX09103-101-035] ; National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program, China[2012ZX09301001-001] ; "Interdisciplinary Cooperation Team" Program for Science and Technology Innovation (CAS)[00000000] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica[SIMM1302KF-08]
WOS关键词	C-H ACTIVATION ; N BOND FORMATION ; INTERNAL ALKYNES ; ANTIBACTERIAL ACTIVITY ; ANTICANCER AGENTS ; SALTS ; DERIVATIVES ; CYCLIZATION ; ANNULATION ; CLEAVAGE
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000333196000009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277151]
专题	药物化学研究室
通讯作者	Zhang, Ao
作者单位	1.Chinese Acad Sci, SOMCL, SIMM, Shanghai 201203, Peoples R China 2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China; 3.Chinese Acad Sci, CAS Key Lab Receptor Res, SIMM, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Xing, Li,Fan, Zhoulong,Hou, Chengyu,et al. Synthesis of Pyrazolo[1,2-a] cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach[J]. ADVANCED SYNTHESIS & CATALYSIS,2014,356(5):972-976.
APA	Xing, Li,Fan, Zhoulong,Hou, Chengyu,Yong, Guoping,&Zhang, Ao.(2014).Synthesis of Pyrazolo[1,2-a] cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach.ADVANCED SYNTHESIS & CATALYSIS,356(5),972-976.
MLA	Xing, Li,et al."Synthesis of Pyrazolo[1,2-a] cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach".ADVANCED SYNTHESIS & CATALYSIS 356.5(2014):972-976.