MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling | |
Xiao, F.; Qiu, H.; Cui, H.; Ni, X.; Li, J.; Liao, W.; Lu, L.; Ding, K.![]() | |
刊名 | ONCOGENE
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2015-04-09 | |
卷号 | 34期号:15页码:1968-1978 |
ISSN号 | 0950-9232 |
DOI | 10.1038/onc.2014.134 |
文献子类 | Article |
英文摘要 | The previous studies in this lab discovered that microRNA-885-3p (miR-885-3p) was regulated by a sulfated polysaccharide that bound to bone morphogenetic protein receptor, type IA (BMPR1A) to inhibit angiogenesis. However, its specific role and its mechanism of action in tumor cells have not been elucidated. We show that miR-885-3p markedly suppresses angiogenesis in vitro and in vivo. MiR-885-3p inhibits Smad1/5/8 phosphorylation and downregulates DNA-binding protein inhibitor ID-1 (Id1), a proangiogenic factor, by targeting BMPR1A, leading to impaired angiogenesis. Overexpression or silencing of BMPR1A affects angiogenesis in a Smad/Id1-dependent manner. We further show that miR-885-3p impairs the growth of HT-29 colon cancer cell xenografts in nude mice by suppressing angiogenesis through disruption of BMPR1A and Smad/Id1 signaling. These results support a novel role for miR-885-3p in tumor angiogenesis by targeting BMPR1A, which regulates a proangiogenic factor, and provide new evidence that targeting miRNAs might be an effective therapeutic strategy for improving colon cancer treatment. |
资助项目 | National Natural Science Foundation of China (NSFC)[81171914] ; National Natural Science Foundation of China (NSFC)[31230022] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund for Distinguished Young Scholars in China[81125025] |
WOS关键词 | BONE MORPHOGENETIC PROTEIN ; TUMOR ANGIOGENESIS ; JUVENILE POLYPOSIS ; COLORECTAL-CANCER ; EXPRESSION ; ID1 ; GENES ; DICER ; MICE ; RNAS |
WOS研究方向 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000352725600011 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/276575] ![]() |
专题 | 药理学第三研究室 |
通讯作者 | Ding, K. |
作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Xiao, F.,Qiu, H.,Cui, H.,et al. MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling[J]. ONCOGENE,2015,34(15):1968-1978. |
APA | Xiao, F..,Qiu, H..,Cui, H..,Ni, X..,Li, J..,...&Ding, K..(2015).MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling.ONCOGENE,34(15),1968-1978. |
MLA | Xiao, F.,et al."MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling".ONCOGENE 34.15(2015):1968-1978. |
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