Identification of novel long non-coding RNAs in triple-negative breast cancer

doi:10.18632/oncotarget.4419

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	Identification of novel long non-coding RNAs in triple-negative breast cancer
	Shen, Xiaokun 3,4; Xie, Bojian 4; Ma, Zhaosheng 4; Yu, Wenjie 4; Wang, Wenmin 4; Xu, Dong 4; Yan, Xinqiang 4; Chen, Beibei 2; Yu, Longyao 1; Li, Jicheng 3
刊名	ONCOTARGET
	2015-08-28
卷号	6 期号:25 页码:21730-21739
关键词	triple-negative breast carcinomas long non-coding RNAs
ISSN号	1949-2553
DOI	10.18632/oncotarget.4419
文献子类	Article
英文摘要	Triple-negative breast carcinomas (TNBC) are characterized by particularly poor outcomes, and there are no established markers significantly associated with prognosis. Long non-coding RNAs (lncRNAs) are subclass of noncoding RNAs that have been recently shown to play critical roles in cancer biology. However, little is known about their mechanistic role in TNBC pathogenesis. In this report, we investigated the expression patterns of lncRNAs from TNBC tissues and matched normal tissues with Agilent Human lncRNA array. We identified 1,758 lncRNAs and 1,254 mRNAs that were differentially expressed (>= 2-fold change), indicating that many lncRNAs are significantly upregulated or downregulated in TNBC. Among these, XR_250621.1 and NONHSAT125629 were the most upregulated and downregulated lncRNAs respectively. qRT-PCR was employed to validate the microarray analysis findings, and results were consistent with the data from the microarrays. GO and KEGG pathway analysis were applied to explore the potential lncRNAs functions, some pathways including microtubule motor activity and DNA replication were identified in TNBC pathogenesis. Our study revealed that a set of lncRNAs were differentially expressed in TNBC tissues, suggesting that they may play role in TNBC. These results shed light on lncRNAs' biological functions and provide useful information for exploring potential therapeutic targets for breast cancer.
资助项目	National Science Foundation for Distinguished Young Scholars of China[81125025] ; National Natural Science Foundation of China[81202103] ; National Natural Science Foundation of China[31370810] ; National Natural Science Foundation of China[81172240] ; National Natural Science Foundation of China[81472714] ; National Natural Science Foundation of China[81171914] ; Zhejiang Provincial Natural Science Foundation of China[LY15H160002] ; Henan outstanding youth fund projects[2014011016]
WOS关键词	METASTASIS ; DOWNSTREAM ; CELLS ; GAS5
WOS研究方向	Oncology ; Cell Biology
语种	英语
出版者	IMPACT JOURNALS LLC
WOS记录号	WOS:000360969200080
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276431]
专题	药理学第三研究室
通讯作者	Chen, Xiaobing
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycobiol & Glycochem Lab, Shanghai 200031, Peoples R China 2.Zhengzhou Univ, Affiliated Canc Hosp, Hennan Canc Hosp, Dept Internal Oncol, Zhengzhou 450052, Hennan, Peoples R China; 3.Zhejiang Univ, Inst Cell Biol, Hangzhou 310003, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Taizhou Hosp, Dept Surg Oncol, Taizhou, Zhejiang, Peoples R China;
推荐引用方式 GB/T 7714	Shen, Xiaokun,Xie, Bojian,Ma, Zhaosheng,et al. Identification of novel long non-coding RNAs in triple-negative breast cancer[J]. ONCOTARGET,2015,6(25):21730-21739.
APA	Shen, Xiaokun.,Xie, Bojian.,Ma, Zhaosheng.,Yu, Wenjie.,Wang, Wenmin.,...&Cao, Feilin.(2015).Identification of novel long non-coding RNAs in triple-negative breast cancer.ONCOTARGET,6(25),21730-21739.
MLA	Shen, Xiaokun,et al."Identification of novel long non-coding RNAs in triple-negative breast cancer".ONCOTARGET 6.25(2015):21730-21739.