Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon

doi:10.1021/acs.orglett.7b00089

	Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon
	Wu, Xiaowei 1,3; Wang, Bao 1,2; Zhou, Yu1 ; Liu, Hong1
刊名	ORGANIC LETTERS
	2017-03-17
卷号	19 期号:6 页码:1294-1297
ISSN号	1523-7060
DOI	10.1021/acs.orglett.7b00089
文献子类	Article
英文摘要	Herein, rhodium(III)-catalyzed C-H activation/subsequent [4 + 1] cyclization reactions between benzamides and propargyl alcohols are reported in which propargyl alcohols serve as unusual one carbon units. This title transformation led to a series of isoindolinones bearing a quaternary carbon with moderate to good yields without the requirement for external metal oxidants. Due to the mild and simple reaction conditions, this reaction is compatible with various functional groups.
资助项目	National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21602234] ; National Natural Science Foundation of China[81220108025] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB91 0304]
WOS关键词	OXYGEN-ATOM TRANSFER ; FORM GAMMA-LACTAMS ; INTERNAL OXIDANT ; O BOND ; DIRECTING GROUP ; ISOQUINOLONE SYNTHESIS ; EFFICIENT SYNTHESIS ; INDOLE SYNTHESIS ; FACILE SYNTHESIS ; 4+1 ANNULATION
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000397077400008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272738]
专题	药物化学研究室药物安全性评价中心
通讯作者	Liu, Hong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
推荐引用方式 GB/T 7714	Wu, Xiaowei,Wang, Bao,Zhou, Yu,et al. Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon[J]. ORGANIC LETTERS,2017,19(6):1294-1297.
APA	Wu, Xiaowei,Wang, Bao,Zhou, Yu,&Liu, Hong.(2017).Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon.ORGANIC LETTERS,19(6),1294-1297.
MLA	Wu, Xiaowei,et al."Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon".ORGANIC LETTERS 19.6(2017):1294-1297.