Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael-Henry cascade reactions

doi:10.3762/bjoc.13.131

	Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael-Henry cascade reactions
	Du, Yonglei 1; Li, Jian 3; Chen, Kerong 3; Wu, Chenglin 3; Zhou, Yu3 ; Liu, Hong2,3
刊名	BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
	2017-07-07
卷号	13 页码:1342-1349
关键词	asymmetric synthesis four consecutive stereocenters Michael-Henry cascade reactions spirocyclopentaneoxindoles thioureas
ISSN号	1860-5397
DOI	10.3762/bjoc.13.131
文献子类	Article
英文摘要	The thiourea-catalyzed asymmetric synthesis of highly enantioenriched spirocyclopentaneoxindoles containing chiral amide functional groups using simple 3-substituted oxindoles and nitrovinylacetamide as starting materials was achieved successfully. This protocol features operational simplicity, high atom economy, and high catalytic asymmetry, thus representing a versatile approach to the synthesis of highly enantioenriched spirocyclopentaneoxindoles.
资助项目	National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81220108025] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; National S&T Major Projects[2014ZX09507002-001]
WOS关键词	BAYLIS-HILLMAN CARBONATES ; SPIROOXINDOLE DERIVATIVES ; NATURAL-PRODUCTS ; ENANTIOSELECTIVE SYNTHESIS ; 3+2 ANNULATION ; PYRROLIDINE SULFONAMIDE ; SPIROCYCLIC OXINDOLES ; ADDITION-REACTIONS ; ALDEHYDES ; NITROOLEFINS
WOS研究方向	Chemistry
语种	英语
出版者	BEILSTEIN-INSTITUT
WOS记录号	WOS:000405432300001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272570]
专题	药物化学研究室药理学第一研究室
通讯作者	Zhou, Yu; Liu, Hong
作者单位	1.Univ Sci & Technol China, Nano Sci & Technol Inst, 166 Ren Ai Rd, Suzhou 215123, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Du, Yonglei,Li, Jian,Chen, Kerong,et al. Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael-Henry cascade reactions[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2017,13:1342-1349.
APA	Du, Yonglei,Li, Jian,Chen, Kerong,Wu, Chenglin,Zhou, Yu,&Liu, Hong.(2017).Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael-Henry cascade reactions.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,13,1342-1349.
MLA	Du, Yonglei,et al."Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael-Henry cascade reactions".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 13(2017):1342-1349.