A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study | |
Cai, Deqin2,3; Yao, Yanli2,3; Tang, Yubo1,5; Wang, Zheng2,4; Shi, Wei1,3; Huang, Wei1,3; Ding, Kan2,3 | |
刊名 | POLYMERS |
2017-10 | |
卷号 | 9期号:10 |
关键词 | arabinogalactan pancreatic cancer gemcitabine resistance carbohydrate chemistry |
ISSN号 | 2073-4360 |
DOI | 10.3390/polym9100536 |
文献子类 | Article |
英文摘要 | RN1, a polysaccharide from flowers of Panax pseudo-ginsieng Wall. Var. notoginseng (Burkill) Hoo & Tseng, is a potential multi-targeting drug candidate for pancreatic cancer treatment. However, the active targeting domain of RN1 is still unknown. Herein, three RN1 derived branches were synthesized via [3+2] or [2+2] strategies, efficiently. Two pentasaccharides, 18 and 27, showed similar inhibition effect on pancreatic cancer BxPC-3 cells to that of RN1 at same concentration. Interestingly, tetrasaccharide 21 potently inhibited gemcitabineresistant cell line Panc-1 at high concentration. These suggest that the branches of RN1 might be the active targeting domain and tetrasaccharide 21 might be a potential leading compound for pancreatic cancer with gemcitabine resistance. |
资助项目 | New Drug Creation and Manufacturing Program[2017ZX09305-003] ; Ministry of Science and Technology, the People Republic of China[00000000] ; State Key Program of National Natural Science Foundation of China[31230022] ; Program of Shanghai Subject Chief Scientist[16XD1404500] ; Innovation Drug Institute of Chinese Academy of Sciences[CASIMM0120154024] ; National Natural Science Foundation of China (NSFC)[31670814] |
WOS关键词 | CELL-GROWTH ; INHIBITOR ; GLYCOSYLATION |
WOS研究方向 | Polymer Science |
语种 | 英语 |
出版者 | MDPI AG |
WOS记录号 | WOS:000414913800074 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/272461] |
专题 | 生物技术药物研发中心(筹) 药理学第三研究室 |
通讯作者 | Ding, Kan |
作者单位 | 1.Chinese Acad Sci, CAS Key Lab Receptor Res, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 4.Univ Sci & Technol China, Nano Sci & Technol Inst, 96 Jin Zhai Rd, Hefei 230026, Anhui, Peoples R China 5.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China; |
推荐引用方式 GB/T 7714 | Cai, Deqin,Yao, Yanli,Tang, Yubo,et al. A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study[J]. POLYMERS,2017,9(10). |
APA | Cai, Deqin.,Yao, Yanli.,Tang, Yubo.,Wang, Zheng.,Shi, Wei.,...&Ding, Kan.(2017).A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study.POLYMERS,9(10). |
MLA | Cai, Deqin,et al."A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study".POLYMERS 9.10(2017). |
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