Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules

doi:10.1016/bs.apcsb.2018.01.004

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules
	He, Yang 1,2; Li, Feng 3; Huang, Yongzhuo1,2
刊名	THERAPEUTIC PROTEINS AND PEPTIDES
	2018
卷号	112 页码:183-220
ISSN号	1876-1623
DOI	10.1016/bs.apcsb.2018.01.004
文献子类	Review; Book Chapter
英文摘要	Many therapeutic macromolecules must enter cells to take their action. However, their treatment outcomes are often hampered by their poor transportation into target cells. Therefore, efficient intracellular delivery of these macromolecules is critical for improving their therapeutic efficacy. Cell-penetrating peptide (CPP)-based approaches are one of the most efficient methods for intracellular delivery of macromolecular therapeutics. Nevertheless, poor specificity is a significant concern for systemic administrated CPP-based delivery systems. This chapter will review recent advances in CPP-mediated macromolecule delivery with a focus on various smart strategies which not only enhance the intracellular delivery but also improve the targeting specificity.
WOS关键词	HUMAN IMMUNODEFICIENCY VIRUS ; ANTICANCER DRUG-DELIVERY ; TARGETED CANCER-THERAPY ; TUMOR-SPECIFIC THERAPY ; PROOF-OF-CONCEPT ; IN-VIVO ; PROTEIN TRANSDUCTION ; PHARMACEUTICAL NANOCARRIERS ; MEDIATED DELIVERY ; GENE DELIVERY
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER ACADEMIC PRESS INC
WOS记录号	WOS:000436624100007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272309]
专题	药物制剂研究中心药物化学研究室
通讯作者	Li, Feng; Huang, Yongzhuo
作者单位	1.Univ Chinese Acad Sci, Beijing, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China; 3.Auburn Univ, Harrison Sch Pharm, Auburn, AL 36849 USA
推荐引用方式 GB/T 7714	He, Yang,Li, Feng,Huang, Yongzhuo. Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules[J]. THERAPEUTIC PROTEINS AND PEPTIDES,2018,112:183-220.
APA	He, Yang,Li, Feng,&Huang, Yongzhuo.(2018).Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules.THERAPEUTIC PROTEINS AND PEPTIDES,112,183-220.
MLA	He, Yang,et al."Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules".THERAPEUTIC PROTEINS AND PEPTIDES 112(2018):183-220.