Synthesis and Biological Activities of Novel Small-molecule GLP-1 Receptor Allosteric Regulators

	Synthesis and Biological Activities of Novel Small-molecule GLP-1 Receptor Allosteric Regulators
	Wang Lei 4; Guo Bin2
刊名	Chinese Journal of Synthetic Chemistry
	2018
卷号	26 期号:8 页码:545-556
关键词	GLP-1 receptor allosteric modulator indolopyridone synthesis structure activity relationship
ISSN号	1005-1511
其他题名	新型小分子GLP-1受体别构调节剂的合成及其活性
文献子类	Article
英文摘要	As a potent drug for patients with type Ⅱ diabetes, GLP-1 receptor agonist can also exert good neuroprotective effects on both the central and peripheral nervous system, highlighting its potential value in the treatment of neurological diseases such as Alzheimer's disease, Parkinson's disease and so on. In this paper, fourteen novel indolopyridone compounds based on small-molecule GLP-1 receptor allosteric regulator were synthesized through systemic structural optimization, and the activity of these compounds were evaluated. The structures were characterized by ~1H NMR, ~(13)C NMR and HR-MS(ESI). The results revealed that some of the compounds had allosteric modulatory effects on either GLP-1(7-36) or GLP-1(9-36).
WOS研究方向	Chemistry (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:6319232
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269161]
专题	药物化学研究室
通讯作者	Guo Bin
作者单位	1.Nanchang; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai 201203, China. 3.; 4.College of Pharmacy, Jiangxi Medical College, Nanchang University; 5.Chinese Academy of Sciences,;
推荐引用方式 GB/T 7714	Wang Lei,Guo Bin. Synthesis and Biological Activities of Novel Small-molecule GLP-1 Receptor Allosteric Regulators[J]. Chinese Journal of Synthetic Chemistry,2018,26(8):545-556.
APA	Wang Lei,&Guo Bin.(2018).Synthesis and Biological Activities of Novel Small-molecule GLP-1 Receptor Allosteric Regulators.Chinese Journal of Synthetic Chemistry,26(8),545-556.
MLA	Wang Lei,et al."Synthesis and Biological Activities of Novel Small-molecule GLP-1 Receptor Allosteric Regulators".Chinese Journal of Synthetic Chemistry 26.8(2018):545-556.