Diverse lignans with anti-inflammatory activity from Urceola rosea

doi:10.1016/j.fitote.2019.02.011

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Diverse lignans with anti-inflammatory activity from Urceola rosea
	Dong, Dou-Dou 3,4; Li, Heng 1,2; Jiang, Kun 4; Qu, Shijin4 ; Tang, Wei1 ; Tan, Changheng4 ; Li, Yiming 3
刊名	Fitoterapia
	2019-04
卷号	134 页码:96-100
关键词	Anti-inflammation Lignans Raw264.7 Cells Sesquineolignans Urceola Rosea
DOI	10.1016/j.fitote.2019.02.011
文献子类	Article
英文摘要	Seventeen structurally diverse lignans, comprising six new compounds, ecdysanols A (1), B (11), C - E (13-15), and F (17), were isolated from the caulis of Urceola rosea. The structures and absolute configurations of these new compounds were elucidated by means of extensive analysis of mass and NMR data, as well as chiroptical properties. A bioassay in vitro showed that all lignans possessed anti-inflammatory effects by inhibiting the production of TNF-alpha, NO and/or IL-6 in LPS-stimulated RAW264.7 cells. Ecdysanol F (17) showed the most strongly effect against NO and IL-6 levels.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279982]
专题	天然药物化学研究室
通讯作者	Tan, Changheng; Li, Yiming
作者单位	1.Laboratory of Antiinflammation & Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China 2.School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China 3.School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 4.Department of Natural medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
推荐引用方式 GB/T 7714	Dong, Dou-Dou,Li, Heng,Jiang, Kun,et al. Diverse lignans with anti-inflammatory activity from Urceola rosea[J]. Fitoterapia,2019,134:96-100.
APA	Dong, Dou-Dou.,Li, Heng.,Jiang, Kun.,Qu, Shijin.,Tang, Wei.,...&Li, Yiming.(2019).Diverse lignans with anti-inflammatory activity from Urceola rosea.Fitoterapia,134,96-100.
MLA	Dong, Dou-Dou,et al."Diverse lignans with anti-inflammatory activity from Urceola rosea".Fitoterapia 134(2019):96-100.