Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats

doi:10.1016/j.nlm.2013.03.005

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	Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats
	Kang, Shuo 1; Ling, Qing-lan 1; Liu, Wen-tao 2; Lu, Bin 1; Liu, Yao 1; He, Lin 2; Liu, Jing-gen1
刊名	NEUROBIOLOGY OF LEARNING AND MEMORY
	2013-07
卷号	103 页码:3-10
关键词	RhoA Neuroplasticity Aging Working memory Dorsal Striatum
ISSN号	1074-7427
DOI	10.1016/j.nlm.2013.03.005
文献子类	Article
英文摘要	The effect of aging on learning and memory has been intensively studied. However, the mechanisms underlying impairment of memory functions at middle age remains inexplicit. To address this question, we assessed the spatial working memory and long-term memory of middle-aged (16-18 months) rats with delayed alternation in T-maze and water maze task respectively. We observed a significant impairment of spatial working memory in middle-aged rats in delayed alternation in T-Maze task, while long-term spatial memory remained unchanged. To further explore possible mechanisms underlying this age-associated impairment of spatial working memory, we examined the activity of RhoA in the prefrontal cortex, dorsal hippocampus, dorsal striatum and sensorimotor cortex. We found that middle-aged rats showed a significant decrease in RhoA activity in dorsal striatum but not in other regions examined, while the protein level remained unchanged compared to the young rats (2-3 months). Moreover, we found that microinfusion of Y-27632, a specific inhibitor of the ROCK that is a downstream effector of RhoA, into dorsal striatum of young rats also impaired their working memory tested in delayed alternation in T Maze task. These results suggest that RhoA activity in dorsal striatum may play a role in mediating spatial working memory. (C) 2013 Elsevier Inc. All rights reserved.
资助项目	Ministry of Science and Technology of China[2009CB522005] ; Foundation of National Natural Science of China[81130087] ; Foundation of National Natural Science of China[81001424]
WOS关键词	LONG-TERM POTENTIATION ; DELAYED ALTERNATION PERFORMANCE ; SYNAPTIC PLASTICITY ; SPATIAL MEMORY ; ENVIRONMENTAL ENRICHMENT ; GENE-EXPRESSION ; PROTEIN-KINASE ; IN-VIVO ; DEFICITS ; DECLINE
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology ; Psychology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000320293400002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277571]
专题	药理学第二研究室
通讯作者	Liu, Jing-gen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Neuropharmacol, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Dept Pharm, Nanjing, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Kang, Shuo,Ling, Qing-lan,Liu, Wen-tao,et al. Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2013,103:3-10.
APA	Kang, Shuo.,Ling, Qing-lan.,Liu, Wen-tao.,Lu, Bin.,Liu, Yao.,...&Liu, Jing-gen.(2013).Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats.NEUROBIOLOGY OF LEARNING AND MEMORY,103,3-10.
MLA	Kang, Shuo,et al."Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats".NEUROBIOLOGY OF LEARNING AND MEMORY 103(2013):3-10.