Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum

doi:10.1055/s-0034-1382840

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum
	Zhou, Zhen-Fang 1; Kong, Ling-Yi 4; Kurtan, Tibor 3; Liu, Hai-Li 1; Mandi, Attila 3; Li, Jia1 ; Gu, Yu-Cheng 2; Guo, Yue-Wei1
刊名	PLANTA MEDICA
	2014-07
卷号	80 期号:11 页码:949-954
关键词	Meliaceae Xylocarpus granatum phragmalin orthoesters configuration determination biological activity
ISSN号	0032-0943
DOI	10.1055/s-0034-1382840
文献子类	Article
英文摘要	Four new 8,9,30-phragmalin orthoesters (1-4), along with six related known compounds, namely xyloccensins O-S (5-9) and V (10), were isolated and characterized from the twigs and leaves of the Chinese mangrove Xylocarpus granatum. The structures of the new compounds were determined on the basis of extensive spectroscopic analysis and by comparison with those of related known compounds in the literature. The absolute configuration of xyloccensin Q(7) was revised as its enantiomer by X-ray diffraction analysis employing graphite monochromated Cu K alpha radiation (lambda = 1.54178 angstrom) with a Flack parameter of -0.04 and was further secured by a time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. Consequently, the absolute configurations of xyloccensins O (5), P (6), R (8), S (9), and V (10) were all corrected as their corresponding enantiomers, respectively. Xyloccensin S (9) exhibited inhibitory activity against protein tyrosine phosphatase 1B, a potential drug target for the treatment of type II diabetes and obesity, with an IC50 value of 8.72 mu g/mL.
资助项目	National Marine '863' Project[2011AA09070102] ; National Marine '863' Project[2013AA092902] ; Natural Science Foundation of China[81273430] ; SKLDR/SIMM Projects[SIMM 1203ZZ-03] ; Syngenta-SIMM-PhD Studentship Project[00000000] ; SKLNM/CPU project[SKLNMKF 201412] ; Hungarian National Research Foundation[OTKA K105871] ; Hungarian National Research Foundation[K81701] ; National Information Infrastructure Development Institute[NIIFI 10038]
WOS关键词	KRISHNA MANGROVE ; LIMONOIDS ; SEEDS ; XYLOMEXICANINS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000340577700014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276994]
专题	天然药物化学研究室
通讯作者	Guo, Yue-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Syngenta Jealotts Hill Int Res Ctr, Bracknell, Berks, England 3.Univ Debrecen, Dept Organ Chem, H-4012 Debrecen, Hungary; 4.China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China;
推荐引用方式 GB/T 7714	Zhou, Zhen-Fang,Kong, Ling-Yi,Kurtan, Tibor,et al. Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum[J]. PLANTA MEDICA,2014,80(11):949-954.
APA	Zhou, Zhen-Fang.,Kong, Ling-Yi.,Kurtan, Tibor.,Liu, Hai-Li.,Mandi, Attila.,...&Guo, Yue-Wei.(2014).Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum.PLANTA MEDICA,80(11),949-954.
MLA	Zhou, Zhen-Fang,et al."Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum".PLANTA MEDICA 80.11(2014):949-954.