The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study

doi:10.1016/j.jad.2007.11.004

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	The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study
	Zhang, Zhang-Jin 3,4; Tan, Qing-Rong 3; Tong, Yao 4; Li, Qiang 2; Kang, Wan-Hu 2; Zhen, Xue-Chu 5; Post, Robert M.1
刊名	JOURNAL OF AFFECTIVE DISORDERS
	2008-07
卷号	109 期号:1-2 页码:91-97
关键词	carbamazepine unipolar depression major depressive disorder clinical trial
ISSN号	0165-0327
DOI	10.1016/j.jad.2007.11.004
文献子类	Article
英文摘要	Our previous studies have shown the effectiveness of carbamazepine (CBZ) in the treatment of bipolar depression. This double-blind, randomized, placebo-controlled study was designed to further evaluate the efficacy of CBZ in unipolar depressed subjects who never received antidepressant and other psychotherapeutic treatment. A total of 89 patients who had at least two major depressive episodes, but never experienced mania or hypomania, were randomly assigned to treatment with immediate-release CBZ 300-800 mg/daily (n = 51) or placebo (n = 38) for 12 weeks. The primary efficacy was measured using the Hamilton Rating Scale for Depression (HAMD), Montgomery-Asberg Depression Rating Scale (MADRS), and Clinical Global Impression-Severity (CGI-S). The mean final CBZ dose of CBZ-treated patients was 461.6 mg/day. CBZ treatment yielded significantly greater improvements on the three efficacy measures at week 8 through endpoint compared to placebo. Patients assigned to CBZ treatment also had a significantly higher clinical response rate than placebo (74% vs. 42%, p<0.001), as defined for >= 50% reduction in HAMD score. Based on the results of our present and previous studies, we suggest that CBZ might be considered an alternative in the management of certain conditions in major depressive disorder. (C) 2007 Elsevier B.V All rights reserved.
WOS关键词	ANTIEPILEPTIC DRUGS ; BIPOLAR DEPRESSION ; MOOD DISORDERS ; MAJOR DEPRESSION ; HERBAL MEDICINE ; ANTIDEPRESSANTS ; SWITCH ; VENLAFAXINE ; PREVALENCE ; MEDICATION
WOS研究方向	Neurosciences & Neurology ; Psychiatry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000256987300009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272878]
专题	药理学第二研究室
通讯作者	Zhang, Zhang-Jin
作者单位	1.Penn State Sch Med, Hershey, PA USA 2.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Psychiat, Xian 710061, Shannxi, Peoples R China; 3.Fourth Mil Med Univ, Dept Psychiat, Xijing Hosp, Xian 710032, Shannxi, Peoples R China; 4.Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Zhang-Jin,Tan, Qing-Rong,Tong, Yao,et al. The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study[J]. JOURNAL OF AFFECTIVE DISORDERS,2008,109(1-2):91-97.
APA	Zhang, Zhang-Jin.,Tan, Qing-Rong.,Tong, Yao.,Li, Qiang.,Kang, Wan-Hu.,...&Post, Robert M..(2008).The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study.JOURNAL OF AFFECTIVE DISORDERS,109(1-2),91-97.
MLA	Zhang, Zhang-Jin,et al."The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study".JOURNAL OF AFFECTIVE DISORDERS 109.1-2(2008):91-97.