The neuroprotective effect of memantine on methamphetamine-induced cognitive deficits

doi:10.1016/j.bbr.2017.01.042

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	The neuroprotective effect of memantine on methamphetamine-induced cognitive deficits
	Long, Jian-Dong 1,2; Liu, Yao 3; Jiao, Dong-Liang 3; Wang, Yu-Jun1,2 ; Zan, Gui-Ying 1,2; Ju, Yun-Yue 3; Zhao, Min 3; Liu, Jing-Gen1,2
刊名	BEHAVIOURAL BRAIN RESEARCH
	2017-04-14
卷号	323 页码:133-140
关键词	Methamphetamine Memantine Cognitive deficits Apoptosis Prefrontal cortex
ISSN号	0166-4328
DOI	10.1016/j.bbr.2017.01.042
文献子类	Article
英文摘要	Repeated exposure to methamphetamine (METH) can cause severe neurotoxicity to the cortical neurons. In the present study, we investigated the effect of METH on cognitive function deficits, and determined the neuroprotective effects of memantine (MEM) on memory impairment induced by METH. The protein levels of Bcl-2 and cleaved caspase-3 in prefrontal cortex (PFC) were further examined to exploring the underlying mechanism. We found that repeated METH administration impaired long term (24 h) memory retention without affecting short term (5 min) memory retention. Co-administration of MEM with METH before training session significantly improved METH-induced cognitive function. METH significantly decreased expression level of Bcl-2 and increased expression level of cleaved caspase-3 in the PFC. The changes can be prevented by MEM pretreatment. Thus, these results demonstrated that MEM pretreatment reversed METH-induced changes of protein levels of apoptotic-related gene, and produced protective effects against METH-induced cognitive deficits, suggesting the effectiveness of MEM may be due to its anti-apoptotic activity. (C) 2017 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[81271468] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[91232716] ; Shanghai Municipal Health and Family Planning Commission joint research project[2014ZYJB0002] ; Ministry of Science and Technology of China[2013CB835100] ; China Post-doctoral Science Foundation[2014M561482]
WOS关键词	OBJECT RECOGNITION ; INDUCED NEUROTOXICITY ; PREFRONTAL CORTEX ; APOPTOSIS ; RATS ; MITOCHONDRIA ; MECHANISMS ; ADDICTION ; MEMORY ; CELLS
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000397369100016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272699]
专题	药理学第二研究室
通讯作者	Zhao, Min
作者单位	1.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China
推荐引用方式 GB/T 7714	Long, Jian-Dong,Liu, Yao,Jiao, Dong-Liang,et al. The neuroprotective effect of memantine on methamphetamine-induced cognitive deficits[J]. BEHAVIOURAL BRAIN RESEARCH,2017,323:133-140.
APA	Long, Jian-Dong.,Liu, Yao.,Jiao, Dong-Liang.,Wang, Yu-Jun.,Zan, Gui-Ying.,...&Liu, Jing-Gen.(2017).The neuroprotective effect of memantine on methamphetamine-induced cognitive deficits.BEHAVIOURAL BRAIN RESEARCH,323,133-140.
MLA	Long, Jian-Dong,et al."The neuroprotective effect of memantine on methamphetamine-induced cognitive deficits".BEHAVIOURAL BRAIN RESEARCH 323(2017):133-140.