Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats

doi:10.1111/j.1745-7254.2005.00064.x

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats
	Xiao Liang; Zhao Feili; Zhu Xingzu
刊名	Acta Pharmacologica Sinica
	2005
卷号	26 期号:4 页码:441-446
关键词	ischemic preconditioning brain ischemia prostaglandins cyclooxygenase-2
ISSN号	1671-4083
DOI	10.1111/j.1745-7254.2005.00064.x
文献子类	Article
英文摘要	Aim: To examine whether the prostaglandins (PGs) pathway is involved in triggering delayed neuroprotection by ischemic preconditioning (IPC) and evaluate the effects of IPC on cyclooxygenase-2 (COX-2) expression following focal cerebral ischemia and reperfusion in rats. Methods: IPC was induced by 10 min of saline infusion into the left internal carotid artery with the right common carotid artery clamped at the same time. Middle cerebral artery occlusion (MCAO) and reperfusion model was produced using intraluminal filament method. Results: IPC 48 h prior to MCAO significantly reduced infarct area as compared with MCAO alone. A nonselective inhibitor of COX indomethacin (3 mg/kg ip) applied 1 h prior to or 1 h after IPC failed to affect its protective effects. IPC had no direct effect on the cortex COX-2 mRNA and protein expression 72 h later, but decreased the expression of COX-2 mRNA and protein following ischemia and reperfusion insult. Conclusion: PGs pathways was not involved in triggering delayed neuroprotection by IPC, and IPC induced down-regulation of COX-2 following focal cerebral ischemia and reperfusion in rats in vivo.
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	英语
CSCD记录号	CSCD:2000109
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268361]
专题	药理学第二研究室
作者单位	Department of Pharmacology II, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, ShangHai 201203, China.
推荐引用方式 GB/T 7714	Xiao Liang,Zhao Feili,Zhu Xingzu. Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats[J]. Acta Pharmacologica Sinica,2005,26(4):441-446.
APA	Xiao Liang,Zhao Feili,&Zhu Xingzu.(2005).Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats.Acta Pharmacologica Sinica,26(4),441-446.
MLA	Xiao Liang,et al."Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats".Acta Pharmacologica Sinica 26.4(2005):441-446.