Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering

doi:10.1021/acs.cgd.8b01002

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物质量控制与固体化学研究中心

	Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering
	Li, Meiqi 3,4; Zhang, Zhen 1,3; Zhang, Qi 3; Peng, Bo 3; Zhu, Bin 2; Wang, Jian-rong3 ; Liu, Liyu 3,4; Mei, Xuefeng3
刊名	CRYSTAL GROWTH & DESIGN
	2018-10
卷号	18 期号:10 页码:6123-6132
ISSN号	1528-7483
DOI	10.1021/acs.cgd.8b01002
文献子类	Article
英文摘要	Due to the increasing concern of toxicity when using synthetic pigments, naturally occurring materials have regained attention. However, the limited hues and instability restrict their applications. Emodin (EM) is considered as a naturally sourced pigment and has been added in chemic necessities for many years. In this work, continuous color changes can be achieved by careful selection of coformers via a cocrystal engineering approach. This fine color tuning could be attributed to the different pi-pi and charge-transfer interactions after cocrystal formation. Furthermore, EM cocrystals were found to have superior stability in formulations. Fine color modifications and better stability behaviors in cocrystals may provide a new pathway to develop naturally sourced pigments without chemical synthesis.
资助项目	Shanghai Natural Science Foundation[18ZR1447900] ; Youth Innovation Promotion Association CAS[2016257] ; CAS Key Technology Talent Program[00000000] ; SANOFI-SIBS Scholarship[00000000]
WOS关键词	CO-CRYSTAL ; CANCER ; PATHWAY ; SUPPRESSION ; CHEMISTRY ; ANTITUMOR ; OXIDATION ; MICE
WOS研究方向	Chemistry ; Crystallography ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000446923500048
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279558]
专题	药物质量控制与固体化学研究中心
通讯作者	Mei, Xuefeng
作者单位	1.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China; 2.East China Univ Sci & Technol, Sch Pharm, Lab Pharmaceut Crystal Engn & Technol, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
推荐引用方式 GB/T 7714	Li, Meiqi,Zhang, Zhen,Zhang, Qi,et al. Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering[J]. CRYSTAL GROWTH & DESIGN,2018,18(10):6123-6132.
APA	Li, Meiqi.,Zhang, Zhen.,Zhang, Qi.,Peng, Bo.,Zhu, Bin.,...&Mei, Xuefeng.(2018).Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering.CRYSTAL GROWTH & DESIGN,18(10),6123-6132.
MLA	Li, Meiqi,et al."Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering".CRYSTAL GROWTH & DESIGN 18.10(2018):6123-6132.