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	Scrodentoids F-I, four C-19-norditerpenoids from Scrophularia dentata
	Zhang, Liu-qiang2; Zhao, Yuan-yuan2; Huang, Cheng2; Chen, Kai-xian1,2; Li, Yi-ming2
刊名	TETRAHEDRON
	2016-12-08
卷号	72期号:49页码:8031-8035
关键词	Scrophularia dentata C-19-Norditerpenoids Scrodentoids F-I X-ray crystallography FXR agonistic effect
ISSN号	0040-4020
DOI	10.1016/j.tet.2016.10.035
文献子类	Article
英文摘要	Four unprecedented C-19-diterpenoids, scrodentoids F-I (1-4), were isolated from the whole plant of Scrophularia dentata. Among them, scrodentoids H (3) and I (4) were identified to be a pair of epimerides. The structures and absolute configurations were elucidated through spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. Compounds 1-4 and scrodentoid B were tested for their farnesoid X-activate receptor agonistic effect. Compound 1 could moderately activate FXR transactivity in a dose-dependent manner. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	Program of the Excellent Academic Leaders of Shanghai[16XD1403500] ; Program of Shanghai E-institute of Bioactive Constituents in Traditional Chinese Medicine[00000000] ; Funding Scheme for Training Young Teachers in Shanghai Colleges[ZZszy13057]
WOS关键词	ROYLE EX BENTH ; ANTIINFLAMMATORY ACTIVITY ; BILE-ACIDS ; RECEPTOR ; GLYCOSIDES
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000389102700019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275767]
专题	天然药物化学研究室 药物发现与设计中心
通讯作者	Li, Yi-ming
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Medico, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Liu-qiang,Zhao, Yuan-yuan,Huang, Cheng,et al. Scrodentoids F-I, four C-19-norditerpenoids from Scrophularia dentata[J]. TETRAHEDRON,2016,72(49):8031-8035.
APA	Zhang, Liu-qiang,Zhao, Yuan-yuan,Huang, Cheng,Chen, Kai-xian,&Li, Yi-ming.(2016).Scrodentoids F-I, four C-19-norditerpenoids from Scrophularia dentata.TETRAHEDRON,72(49),8031-8035.
MLA	Zhang, Liu-qiang,et al."Scrodentoids F-I, four C-19-norditerpenoids from Scrophularia dentata".TETRAHEDRON 72.49(2016):8031-8035.

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