Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation

doi:10.1016/j.brainres.2017.03.019

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	Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation
	Bian, Minjuan 2,3; Zhang, Yong 1; Du, Xiaoye 2,3; Xu, Jing 4; Cui, Jingang 2,3; Gu, Jiangping 4; Zhu, Weiliang1 ; Zhang, Teng 2,3; Chen, Yu 2,3
刊名	BRAIN RESEARCH
	2017-05-15
卷号	1663 页码:141-150
关键词	Apigenin-7-diglucuronide Photoreceptor degeneration Oxidative stress Retinal inflammation
ISSN号	0006-8993
DOI	10.1016/j.brainres.2017.03.019
文献子类	Article
英文摘要	Vision impairment in retinal degenerative diseases such as age-related macular degeneration is primarily associated with photoreceptor degeneration, in which oxidative stress and inflammatory responses are mechanistically involved as central players. Therapies with photoreceptor protective properties remain to be developed. Apigenin-7-diglucuronide (A7DG), a flavonoid glycoside, is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. However, the pharmacological significance of A7DG remains unknown in vivo. The current study isolated A7DG from Glechoma longituba (Nakai) Kuprian and investigated the retinal protective effect A7DG in mice characterized by bright light-induced photoreceptor degeneration. The results showed that A7DG treatment led to remarkable photoreceptor protection in bright light-exposed BALB/c mice. Moreover, A7DG treatment alleviated photoreceptor apoptosis, mitigated oxidative stress, suppressed reactive gliosis and microglial activation and attenuated the expression of proinflammatory genes in bright light-exposed retinas. The results demonstrated for the first time remarkable photoreceptor protective activities of A7DG in vivo. Inhibition of bright light-induced retinal oxidative stress and retinal inflammatory responses was associated with the retinal protection conferred by A7DG. The work here warrants further evaluation of A7DG as a pharmacological candidate for the treatment of vision-threatening retinal degenerative disorders. Moreover, given the general implication of oxidative stress and inflammation in the pathogenesis of neurodegeneration, A7DG could be further tested for the treatment of other neurodegenerative disorders. (C) 2017 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[81473732] ; National Natural Science Foundation of China[81673790] ; Program of Eastern Scholar - Shanghai Municipal Education Commission[Hu201188] ; Program of Eastern Scholar - Shanghai Municipal Education Commission[GZ2015011] ; Shuguang Project - Shanghai Municipal Education Commission[13SG42] ; Budget Project from Shanghai Municipal Education Commission[2014YSN49] ; Shanghai Sailing Program[16YF1414100]
WOS关键词	APOPTOSIS IN-VITRO ; MACULAR DEGENERATION ; MICROGLIAL ACTIVATION ; PERILLA-FRUTESCENS ; CELLS ; DAMAGE ; CONSTITUENTS ; HYDROETHIDINE ; MECHANISMS ; RPE
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000401046500016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272663]
专题	药物发现与设计中心
通讯作者	Zhang, Teng; Chen, Yu
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Yueyang Hosp, Shanghai 200437, Peoples R China; 3.Shanghai Univ Tradit Chinese Med, Clin Res Inst Integrat Med, Shanghai 200437, Peoples R China; 4.East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
推荐引用方式 GB/T 7714	Bian, Minjuan,Zhang, Yong,Du, Xiaoye,et al. Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation[J]. BRAIN RESEARCH,2017,1663:141-150.
APA	Bian, Minjuan.,Zhang, Yong.,Du, Xiaoye.,Xu, Jing.,Cui, Jingang.,...&Chen, Yu.(2017).Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation.BRAIN RESEARCH,1663,141-150.
MLA	Bian, Minjuan,et al."Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation".BRAIN RESEARCH 1663(2017):141-150.