Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration

doi:10.1038/s41401-018-0011-0

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	Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration
	Liu, Meng 1; Yuan, Jie 2; Hu, Wen-Juan3 ; Ke, Chang-Qiang2 ; Zhang, Yi-Fan3 ; Ye, Yang2 ; Zhong, Da-Fang3 ; Zhao, Guang-Rong 1; Yao, Sheng2 ; Liu, Jia4
刊名	Acta pharmacologica Sinica
	2018-05-17
ISSN号	1745-7254
DOI	10.1038/s41401-018-0011-0
文献子类	Article
英文摘要	The influence of broad-spectrum antibiotics on the pharmacokinetics and biotransformation of major constituents of Shaoyao-Gancao decoction (SGD) in rats was investigated. The pharmacokinetic behaviors of paeoniflorin (PF), albiflorin (AF), liquiritin (LT), isoliquiritin (ILT), liquiritin apioside (LA), isoliquiritin apioside (ILA), and glycyrrhizic acid (GL), seven major constituents of SGD, as well as glycyrrhetinic acid (GA), a major metabolite of GL, were analyzed. A 1-week pretreatment with broad-spectrum antibiotics (ampicillin, metronidazole, neomycin, 1 g L; and vancomycin, 0.5 g L) via drinking water reduced plasma exposure of the major constituents. The AUC of PF and LT was significantly decreased by 28.7% and 33.8% (P < 0.05 and P < 0.005), respectively. Although the differences were not statistically significant, the AUC of AF, ILT, LA, ILA, and GL was decreased by 31.4%, 50.9%, 16.9%, 44.1%, and 37.0%, respectively, compared with the control group. In addition, the plasma GA exposure in the antibiotic-pretreated group was significantly lower (P < 0.005) than the control group. The in vitro stability of the major constituents of SGD in the rat intestinal contents with or without broad-spectrum antibiotics was also investigated. The major constituents were comparatively stable in the rat duodenum contents, and the biotransformation of GL mainly occurred in the rat colon contents. In summary, broad-spectrum antibiotics suppressed the absorption of the major constituents of SGD and significantly inhibited the biotransformation of GL to GA by suppressing the colon microbiota. The results indicated a potential clinical drug-drug interaction (DDI) when SGD was administered with broad-spectrum antibiotics.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266654]
专题	天然药物化学研究室上海药物代谢研究中心
通讯作者	Zhao, Guang-Rong; Yao, Sheng; Liu, Jia
作者单位	1.Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China; 2.State Key Laboratory of Drug Research & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; 4.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. jia
推荐引用方式 GB/T 7714	Liu, Meng,Yuan, Jie,Hu, Wen-Juan,et al. Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration[J]. Acta pharmacologica Sinica,2018.
APA	Liu, Meng.,Yuan, Jie.,Hu, Wen-Juan.,Ke, Chang-Qiang.,Zhang, Yi-Fan.,...&Liu, Jia.(2018).Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration.Acta pharmacologica Sinica.
MLA	Liu, Meng,et al."Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration".Acta pharmacologica Sinica (2018).