Contamination of hepatotoxic pyrrolizidine alkaloids in retail honey in China

doi:10.1016/j.foodcont.2017.10.026

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	Contamination of hepatotoxic pyrrolizidine alkaloids in retail honey in China
	Zhu, Lin 3,5,6; Wang, Zhangting 5,6; Wong, Lailai 7; He, Yisheng 5,6; Zhao, Zhongzhen 7; Ye, Yang1,4,6 ; Fu, Peter P.2; Lin, Ge 5,6
刊名	FOOD CONTROL
	2018-03
卷号	85 页码:484-494
关键词	Food safety China honey Pyrrolizidine alkaloid Pollen analysis LC-MS analysis
ISSN号	0956-7135
DOI	10.1016/j.foodcont.2017.10.026
文献子类	Article
英文摘要	Pyrrolizidine alkaloids (PAs) are natural toxins present in over 6000 plants. Humans are exposed to PAs through the intake of PA-containing plants and/or PA-contaminated foodstuffs, such as honey. PA contamination in honey has been extensively studied in many countries, but rarely investigated in China. The present study investigated PA contamination in retail honey purchased in four representative regions (Hong Kong, Macau, Beijing, Shanghai) in China. Among 120 honey samples tested, 58% of them contained PAs with the concentration range over 0.04-288.07 mu g/kg. The prevalence and content of PAs in honeys purchased in Hong Kong and Macau were significantly higher than those detected in Beijing and Shanghai. Lycopsamine and echimidine were determined as predominant PAs in the contaminated honeys, and their potential botanic sources including plants of Echinni and Senecio genera were identified by pollen analysis. Moreover, clivorine, which has not been reported previously in PA-contaminated honey, was found with a high prevalence (34%) in PA-contaminated honeys in China. Our study represented an integrated report on PA contamination in retail honey in China. The data provided information useful for the global assessment of human risk posed by consumption of PA contaminated honey. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[81603381] ; Research Grant Council of Hong Kong (GRF)[14110714] ; One-off Funding for Joint Lab/Research Collaboration by CUHK[3132968] ; CUHK School of Biomedical Sciences-Seed Fund for Joint Establishments[00000000]
WOS关键词	CHROMATOGRAPHY-MASS-SPECTROMETRY ; HEPATIC VENOOCCLUSIVE DISEASE ; SOLID-PHASE EXTRACTION ; LC-MS ANALYSIS ; LIQUID-CHROMATOGRAPHY ; ECHIUM-VULGARE ; METABOLIC-ACTIVATION ; COMMERCIAL HONEY ; HERBAL TEA ; N-OXIDES
WOS研究方向	Food Science & Technology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000419409000058
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279887]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Lin, Ge
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Natl Ctr Toxicol Res, Jefferson, AR 72079 USA 3.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China; 5.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China; 6.Chinese Acad Sci, Joint Res Lab Promoting Globalizat Tradit Chinese, Beijing, Peoples R China; 7.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China;
推荐引用方式 GB/T 7714	Zhu, Lin,Wang, Zhangting,Wong, Lailai,et al. Contamination of hepatotoxic pyrrolizidine alkaloids in retail honey in China[J]. FOOD CONTROL,2018,85:484-494.
APA	Zhu, Lin.,Wang, Zhangting.,Wong, Lailai.,He, Yisheng.,Zhao, Zhongzhen.,...&Lin, Ge.(2018).Contamination of hepatotoxic pyrrolizidine alkaloids in retail honey in China.FOOD CONTROL,85,484-494.
MLA	Zhu, Lin,et al."Contamination of hepatotoxic pyrrolizidine alkaloids in retail honey in China".FOOD CONTROL 85(2018):484-494.