A novel photocleavable heparin derivative with light controllable anticoagulant activity

doi:10.1016/j.carbpol.2017.12.057

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	A novel photocleavable heparin derivative with light controllable anticoagulant activity
	Sun, Feifei 1,2; Liu, Yinyin 1; Wang, Dongdong 1; Wang, Zhaojie 1; Mu, Haibo 1; Wang, Feng 1; Ding, Kan2 ; Duan, Jinyou 1
刊名	CARBOHYDRATE POLYMERS
	2018-03-15
卷号	184 页码:191-198
关键词	Glycosaminoglycan Heparin Photocaging Anticoagulant
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2017.12.057
文献子类	Article
英文摘要	Heparin (HP) has enormous potential for clinical medication applications owing to its anticoagulant activity. However, the strong anticoagulant capacity of HP also leads to some side effects. Herein, a photocaged derivative (HP-DMNB) of HP was synthesized for light control of its anticoagulant activity. The synthesized HP-DMNB was characterized by NMR and FTIR analysis, which confirmed the successful modification of HP with the photocleavable 4,5-dimethoxyl-2-nitrobenzyl (DMNB) groups. After the modification, the molecular weight of HP-DMNB (DS = 0.34%) changed from 61 to 71 kDa. Anticoagulant activity analysis showed that HP-DMNB had a reduced anticoagulant capacity compared with commercial HP, while its anticoagulant activity will regain after releasing the free carboxyl groups of HP under UV light. In addition, HP-DMNB and its UV irradiated products were observed to possess good biocompatibility through the MTT assays and live-dead assays with HaCaT cells, which may have impacts on the clinical medication applications of HP.
资助项目	National Natural Science Foundation of China (NSFC)[31570799] ; Fundamental Research Funds for the Central Universities, Northwest AF University[2452017026] ; Fundamental Research Funds for the Central Universities, Northwest AF University[Z109021713] ; State Key Laboratory of Drug Research[SIMM1705KF-16]
WOS关键词	ACTINIDIA-CHINENSIS ROOTS ; ANTITHROMBOTIC ACTIVITIES ; CANCER-THERAPY ; FACTOR-XII ; POLYSACCHARIDES ; DELIVERY ; RELEASE ; KERATINOCYTES ; COAGULATION ; ANTIOXIDANT
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000423720500022
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279851]
专题	药理学第三研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Duan, Jinyou
作者单位	1.Northwest A&F Univ, Shaanxi Key Lab Nat Prod & Chem Biol, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Sun, Feifei,Liu, Yinyin,Wang, Dongdong,et al. A novel photocleavable heparin derivative with light controllable anticoagulant activity[J]. CARBOHYDRATE POLYMERS,2018,184:191-198.
APA	Sun, Feifei.,Liu, Yinyin.,Wang, Dongdong.,Wang, Zhaojie.,Mu, Haibo.,...&Duan, Jinyou.(2018).A novel photocleavable heparin derivative with light controllable anticoagulant activity.CARBOHYDRATE POLYMERS,184,191-198.
MLA	Sun, Feifei,et al."A novel photocleavable heparin derivative with light controllable anticoagulant activity".CARBOHYDRATE POLYMERS 184(2018):191-198.