Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities

doi:10.1016/j.phytochem.2018.01.020

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	Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities
	Wang, Wen-qiong; Liu, Shan-shan; Song, Wei-bin; Li, Jun; Xuan, Li-jiang
刊名	PHYTOCHEMISTRY
	2018-05
卷号	149 页码:24-30
关键词	Ipomoea muricata (convolvulaceae) Resin glycosides Multidrug resistance reversal activity
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2018.01.020
文献子类	Article
英文摘要	Resin glycosides represent an important chemotaxonomic marker of the Convolvulaceae family and possess multidrug resistance (MDR) reversal activity. In our recent study, nine previously undescribed resin glycosides, Calonyctins B-J, were isolated from the seeds of Ipomoea muricata. Their structures with the absolute configuration were established on the basis of comprehensive spectroscopic analysis and chemical methods. Among these, Calonyctins F-I possessed a skeleton in which the aglycone moiety and the oligosaccharide core were linked by a 3-hydroxy-2-methylbutanoic acid moiety to form a 25-membered macrocyclic structure. Calonyctins E, J, and muricatic acid C methyl ester were noncytotoxic but enhanced the cytotoxicity of vincristine by 2.5-407.1 fold at 25 mu M in KB/VCR cells. Calonyctin E was the most active one. (C) 2018 Elsevier Ltd. All rights reserved.
资助项目	State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; National Natural Science Foundation of China[81473111] ; National Natural Science Foundation of China[21702219] ; China Postdoctoral Science Foundation[2016M600345]
WOS关键词	INHIBITORS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000430778200003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279779]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Xuan, Li-jiang
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wen-qiong,Liu, Shan-shan,Song, Wei-bin,et al. Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities[J]. PHYTOCHEMISTRY,2018,149:24-30.
APA	Wang, Wen-qiong,Liu, Shan-shan,Song, Wei-bin,Li, Jun,&Xuan, Li-jiang.(2018).Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities.PHYTOCHEMISTRY,149,24-30.
MLA	Wang, Wen-qiong,et al."Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities".PHYTOCHEMISTRY 149(2018):24-30.