The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid

doi:10.1016/j.bmcl.2018.03.062

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	The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid
	Zhang, Wen-Ming 2; Yao, Yang 3,4; Yang, Teng 1,4; Wang, Xue-Ying 2; Zhu, Zhen-Yun 4; Xu, Wen-Tao 2; Lin, Hai-Xia 2; Gao, Zhao-Bing4 ; Zhou, Hu4 ; Yang, Cai-Guang4
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2018-06-01
卷号	28 期号:10 页码:1943-1948
关键词	Antistaphylococcal Multidrug-resistant Synthesis Oxime Dehydroabietic acid
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2018.03.062
文献子类	Article
英文摘要	A series of N-sulfonaminoethyloxime derivatives of dehydroabietic acid were synthesized and investigated for their antibacterial activity against Staphylococcus aureus Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108 and NRS-271). Most of the target compounds having chloro, bromo, trifluoromethyl phenyl moiety exhibited potent in vitro antistaphylococcal activity. The meta-CF3 phenyl derivative T23 showed the highest activity with MIC of 0.39-0.78 mu g/mL against S aureus Newman, while several analogues showed similar potent antibacterial activity with MIC values between 0.78 and 1.56 mu g/mL against five multidrug-resistant S. aureus. The stability of T35 in plasma of SD rat and the cellular cytotoxicity were also evaluated. (C) 2018 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[81202402] ; National Natural Science Foundation of China[81661138004] ; State Key Laboratory of Drug Research[SIMM1501KF-11] ; Program of Shanghai Academic Research Leader[17XD1404400]
WOS关键词	AROMATIC ABIETANE DITERPENOIDS ; STAPHYLOCOCCUS-AUREUS ; ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; BIOLOGICAL-ACTIVITY ; TOTAROL ; BACTERIA ; DESIGN ; C-12
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000432729000048
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279738]
专题	药理学第三研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yang, Cai-Guang; Cui, Yong-Mei
作者单位	1.Guizhou Univ, Ctr Res & Dev Fine Chem, Guiyang 550025, Guizhou, Peoples R China; 2.Shanghai Univ, Coll Sci, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China; 3.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wen-Ming,Yao, Yang,Yang, Teng,et al. The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018,28(10):1943-1948.
APA	Zhang, Wen-Ming.,Yao, Yang.,Yang, Teng.,Wang, Xue-Ying.,Zhu, Zhen-Yun.,...&Cui, Yong-Mei.(2018).The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,28(10),1943-1948.
MLA	Zhang, Wen-Ming,et al."The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28.10(2018):1943-1948.