Tilianin-loaded Reactive Oxygen Species-Scavenging Nano-Micelles Protect H9c2 Cardiomyocyte Against Hypoxia/Reoxygenation-Induced Injury

doi:10.1097/FJC.0000000000000587

	Tilianin-loaded Reactive Oxygen Species-Scavenging Nano-Micelles Protect H9c2 Cardiomyocyte Against Hypoxia/Reoxygenation-Induced Injury
	Wang, Yanfang 2; Wang, Ying 1; Wang, Xinchun 2,3; Hu, Ping 3,4
刊名	JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
	2018-07
卷号	72 期号:1 页码:32-39
关键词	hypoxia/reoxygenation tilianin-loaded micelles oxidative stress inflammation mechanisms
ISSN号	0160-2446
DOI	10.1097/FJC.0000000000000587
文献子类	Article
英文摘要	Previous studies have shown that tilianin alleviates ischemia-reperfusion-induced cardiomyocyte injury. However, its clinical translation has been hampered because of its insolubility in water. Tilianin-based nano-micelles that may overcome this critical issue are presented. A polyethylene glycol compound was covalently attached to propylene sulfide-formed amphiphilic diblock polymers. In the aqueous solution, tilianin is encapsulated in a hydrophobic shell to form nano-micelles. The Ph-PPS-PEG self-assembled into nanoscale micelles with a size of approximately 70 nm, termed "tilianin-loaded micelles" (TLMs). TLMs are highly efficient hydrogen peroxide scavengers and the activity of caspase-3 inhibition, thereby protecting cells from H/R-induced cytotoxicity. In addition, TLMs decreased levels of MDA, IL-1 and tumor necrosis factor (TNF-alpha), inhibited apoptosis, TLR4 and nuclear transcription factor (NF-kappa B p65) protein expression in hypoxia-reoxygenation (H/R) model. Taken together, the study suggests that TLMs may be of clinical value for the protective effects of cardiomyocytes by inhibiting Inflammation and oxidative stress during myocardial ischemia-reperfusion injury.
资助项目	National Natural Science foundation of China[U1203204] ; National Natural Science foundation of China[81360671] ; National Natural Science foundation of China[81460638] ; National Natural Science foundation of China[81660704]
WOS关键词	ISCHEMIA-REPERFUSION INJURY ; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY ; INDUCED APOPTOSIS ; SIGNALING PATHWAY ; OXIDATIVE STRESS ; BLOCK-COPOLYMER ; CELLS ; ANTIOXIDANT ; ROS ; MITOCHONDRIAL
WOS研究方向	Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000440210100007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279677]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Wang, Xinchun; Hu, Ping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai, Peoples R China; 2.Shihezi Univ, Coll Pharm, Xinjiang, Peoples R China; 3.Shihezi Univ, Affiliated Hosp 1, Med Coll, Xin Jiang, Peoples R China; 4.Chongqing Univ, Sch Pharmaceut Sci, Chongqing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yanfang,Wang, Ying,Wang, Xinchun,et al. Tilianin-loaded Reactive Oxygen Species-Scavenging Nano-Micelles Protect H9c2 Cardiomyocyte Against Hypoxia/Reoxygenation-Induced Injury[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,2018,72(1):32-39.
APA	Wang, Yanfang,Wang, Ying,Wang, Xinchun,&Hu, Ping.(2018).Tilianin-loaded Reactive Oxygen Species-Scavenging Nano-Micelles Protect H9c2 Cardiomyocyte Against Hypoxia/Reoxygenation-Induced Injury.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,72(1),32-39.
MLA	Wang, Yanfang,et al."Tilianin-loaded Reactive Oxygen Species-Scavenging Nano-Micelles Protect H9c2 Cardiomyocyte Against Hypoxia/Reoxygenation-Induced Injury".JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 72.1(2018):32-39.