Construction of highly enantiopure beta,beta-diaryl substituted glycine containing two contiguous stereocenters via asymmetric 1,6-conjugate addition

doi:10.1016/j.tet.2018.05.057

	Construction of highly enantiopure beta,beta-diaryl substituted glycine containing two contiguous stereocenters via asymmetric 1,6-conjugate addition
	Tong, Junhua 1,2,3,4; Zhao, Liang 1,2,3,4; Li, Huihui 1,2,3,4; Wu, Chenglin 1,3,4; Han, Xu 1,3,4; Wang, Jiang1,3,4 ; Liu, Hong1,3,4
刊名	TETRAHEDRON
	2018-07-05
卷号	74 期号:27 页码:3755-3760
关键词	beta,beta-diaryl substituted glycine Ni(II)-Complex of glycine 1,6-Conjugate addition para-quinone methides
ISSN号	0040-4020
DOI	10.1016/j.tet.2018.05.057
文献子类	Article
英文摘要	Asymmetric construction of beta,beta-diaryl substituted glycine bearing two contiguous chiral centers remains a significant challenge. Herein, the application of the para-quinone methides (p-QMs) and Ni(II)- complex of glycine via 1,6-conjugate addition to achieve asymmetric synthesis of beta,beta-diaryl substituted glycine has been explored successfully. This protocol features operational simplicity, high diastereoselectivity, and recyclable chiral ligand, which provides a versatile approach to the synthesis of highly enantiopure beta,beta-diaryl substituted glycine. (C) 2018 Published by Elsevier Ltd.
资助项目	National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21672231] ; National Natural Science Foundation of China[21602234] ; National Natural Science Foundation of China[21472209] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; Shanghai Science and Technology Development Fund[15QA1404400]
WOS关键词	PARA-QUINONE METHIDES ; ALPHA-AMINO-ACIDS ; CHIRAL NICKEL(II) GLYCINATE ; ENANTIOSELECTIVE SYNTHESIS ; DERIVATIVES ; ESTERS
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000436218100036
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279663]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Wang, Jiang; Liu, Hong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Univ Sci & Technol China, Nano Sci & Technol Inst, 166 Ren Ai Rd, Suzhou 215123, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, 19A Yu Quan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tong, Junhua,Zhao, Liang,Li, Huihui,et al. Construction of highly enantiopure beta,beta-diaryl substituted glycine containing two contiguous stereocenters via asymmetric 1,6-conjugate addition[J]. TETRAHEDRON,2018,74(27):3755-3760.
APA	Tong, Junhua.,Zhao, Liang.,Li, Huihui.,Wu, Chenglin.,Han, Xu.,...&Liu, Hong.(2018).Construction of highly enantiopure beta,beta-diaryl substituted glycine containing two contiguous stereocenters via asymmetric 1,6-conjugate addition.TETRAHEDRON,74(27),3755-3760.
MLA	Tong, Junhua,et al."Construction of highly enantiopure beta,beta-diaryl substituted glycine containing two contiguous stereocenters via asymmetric 1,6-conjugate addition".TETRAHEDRON 74.27(2018):3755-3760.