Oncogene-induced senescence: a double edged sword in cancer

doi:10.1038/aps.2017.198

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	Oncogene-induced senescence: a double edged sword in cancer
	Liu, Xue-ling; Ding, Jian; Meng, Ling-hua
刊名	ACTA PHARMACOLOGICA SINICA
	2018-10
卷号	39 期号:10 页码:1553-1558
关键词	cellular senescence oncogene SASP tumor microenvironment cancer therapy
ISSN号	1671-4083
DOI	10.1038/aps.2017.198
文献子类	Review
英文摘要	Oncogene-induced cellular senescence (OIS) is a complex program that is triggered in response to aberrant activation of oncogenic signaling. Initially, OIS was thought to be a barrier to malignant transformation because of its suppression on cell proliferation. Later studies showed that senescence induced by oncogenes can also promote the initiation and development of cancer. The opposing effects of OIS occur through different combinations of downstream effectors as well as the interplay of senescent cells and the microenvironment, such as senescence-associated inflammation. Here, we review the common features and molecular mechanisms underlying OIS and the interaction between senescent cells and the microenvironment. We propose that targeting senescent cells may have a beneficial therapeutic effect during the treatment of cancer.
资助项目	National Natural Science Foundation of China[81773760]
WOS关键词	RAS-INDUCED SENESCENCE ; DNA-DAMAGE RESPONSE ; CELLULAR SENESCENCE ; SECRETORY PHENOTYPE ; TUMOR-SUPPRESSOR ; STROMAL FIBROBLASTS ; GROWTH-FACTOR ; CELLS ; SURVEILLANCE ; PROGRESSION
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000448391500001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279554]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Ding, Jian; Meng, Ling-hua
作者单位	Chinese Acad Sci, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xue-ling,Ding, Jian,Meng, Ling-hua. Oncogene-induced senescence: a double edged sword in cancer[J]. ACTA PHARMACOLOGICA SINICA,2018,39(10):1553-1558.
APA	Liu, Xue-ling,Ding, Jian,&Meng, Ling-hua.(2018).Oncogene-induced senescence: a double edged sword in cancer.ACTA PHARMACOLOGICA SINICA,39(10),1553-1558.
MLA	Liu, Xue-ling,et al."Oncogene-induced senescence: a double edged sword in cancer".ACTA PHARMACOLOGICA SINICA 39.10(2018):1553-1558.