Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes

doi:10.1016/j.fitote.2018.09.001

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	Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes
	Yang, Fei 1; Zhang, Liang-Wei 1; Feng, Mei-Tang 1; Liu, Ai-Hong 2; Li, Jia3 ; Zhao, Tian-Sheng 1; Lai, Xiao-Ping 1; Wang, Bin 1; Guo, Yue-Wei3 ; Mao, Shui-Chun 1
刊名	FITOTERAPIA
	2018-10
卷号	130 页码:241-246
关键词	Dictyotaceae Dictyopteris undulate Cholestane-type sterols Dictyoptesterols A-C Protein tyrosine phosphatase-1B inhibitors
ISSN号	0367-326X
DOI	10.1016/j.fitote.2018.09.001
文献子类	Article
英文摘要	Three new cholestane-type sterols bearing an unusual Delta(22)-24-oxo side chain, namely, dictyoptesterols A-C (1-3), were isolated from the brown alga Dictyopteris undulata Holmes, together with five known strutural analogues (4-8). Their structures were elucidated on the basis of by extensive spectroscopic analysis. The absolute configurations of the steroidal nuclei of the new compounds were proposed by a comparison of NMR data with those of related known compounds as well as biogenetic considerations. All of the isolates were evaluated in vitro for their potential to inhibit protein tyrosine phosphatase-1B (PTP1B) activity. The results showed that compounds 1-5 exhibited different levels of PTP1B inhibitory activities with IC50 values ranging from 3.03 +/- 0.76 to 15.01 +/- 2.88 mu M. In particular, compounds 3 and 4 showed promising inhibitory effects towards PTP1B with IC50 values of 3.03 +/- 0.76 and 3.72 +/- 0.40 mu M, respectively, when compared to the positive control oleanolic acid (IC50, 2.83 +/- 0.39 mu M). The chemotaxonomic significance of these isolated Delta(22)-24-oxo cholestanes has also been discussed.
资助项目	National Natural Science Foundation of China[81860616] ; National Natural Science Foundation of China[21362024] ; National Natural Science Foundation of China[21162016] ; Natural Science Foundation of Jiangxi Province, China[20181BAB205086] ; Natural Science Foundation of Jiangxi Province, China[20161BAB205211] ; Natural Science Foundation of Jiangxi Province, China[20151BAB205082] ; State Key Laboratory of Drug Research-SIMM[SIMM1803KF-01]
WOS关键词	CAULERPA-RACEMOSA ; 1B ; SESQUITERPENE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000449129500038
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279551]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室天然药物化学研究室药物安全性评价中心
通讯作者	Mao, Shui-Chun
作者单位	1.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China; 2.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Jiangxi, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yang, Fei,Zhang, Liang-Wei,Feng, Mei-Tang,et al. Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes[J]. FITOTERAPIA,2018,130:241-246.
APA	Yang, Fei.,Zhang, Liang-Wei.,Feng, Mei-Tang.,Liu, Ai-Hong.,Li, Jia.,...&Mao, Shui-Chun.(2018).Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes.FITOTERAPIA,130,241-246.
MLA	Yang, Fei,et al."Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes".FITOTERAPIA 130(2018):241-246.