Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis

doi:10.1002/advs.201801012

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	Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis
	Tan, Tao 1,2,3; Wang, Hong 1,3; Cao, Haiqiang 1,3; Zeng, Lijuan 2; Wang, Yuqi 1,2,3; Wang, Zhiwan 1,3; Wang, Jing 1,3; Li, Jie 1,3; Wang, Siling 2; Zhang, Zhiwen1,3
刊名	ADVANCED SCIENCE
	2018-12
卷号	5 期号:12
关键词	cancer metastasis cancer stem cells deep tumor penetration drug delivery nanocages
ISSN号	2198-3844
DOI	10.1002/advs.201801012
文献子类	Article
英文摘要	Cancer stem cells (CSCs) are proposed to account for the initiation of cancer metastasis, but their accessibility remains a great challenge. This study reports deep tumor-penetrated biomimetic nanocages to augment the accessibility to CSCs fractions in tumor for anti-metastasis therapy. The nanocages can load photothermal agent of 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DBN) and chemotherapeutic epirubicin (EBN) to eradicate CSCs for photothermal-chemotherapy of breast cancer metastasis. In metastatic 4T1-indcued tumor model, both DBN and EBN can efficiently accumulate in tumor sites and feasibly permeate throughout the tumor mass. These biomimetic nanosystems can be preferentially internalized by cancer cells and effectively accessed to CSCs fractions in tumor. The DBN+laser/EBN treatment produces considerable depression of primary tumor growth, drastically eradicates around 80% of CSCs fractions in primary tumor, and results in 95.2% inhibition of lung metastasis. Thus, the biomimetic nanocages can be a promising delivery nanovehicle with preferential CSCs-accessibility for effective anti-metastasis therapy.
资助项目	National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[00000000]
WOS关键词	FERRITIN NANOCAGES ; LUNG METASTASIS ; IN-VIVO ; NANOPARTICLES ; THERAPY ; TARGETS ; DOXORUBICIN ; FIBROBLASTS ; INHIBITION ; CHALLENGES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000453685900012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279472]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Wang, Siling; Zhang, Zhiwen; Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Tan, Tao,Wang, Hong,Cao, Haiqiang,et al. Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis[J]. ADVANCED SCIENCE,2018,5(12).
APA	Tan, Tao.,Wang, Hong.,Cao, Haiqiang.,Zeng, Lijuan.,Wang, Yuqi.,...&Li, Yaping.(2018).Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis.ADVANCED SCIENCE,5(12).
MLA	Tan, Tao,et al."Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis".ADVANCED SCIENCE 5.12(2018).