Copper(I)-Catalyzed One-Pot Synthesis of 2H-1,4-Benzoxazin-3-(4H)-ones from o-Halophenols and 2-Chloroacetamides

doi:10.1021/jo802818s

	Copper(I)-Catalyzed One-Pot Synthesis of 2H-1,4-Benzoxazin-3-(4H)-ones from o-Halophenols and 2-Chloroacetamides
	Feng, Enguang 1; Huang, He 1; Zhou, Yu1 ; Ye, Deju 1; Jiang, Hualiang1,2 ; Liu, Hong1
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2009-04-03
卷号	74 期号:7 页码:2846-2849
ISSN号	0022-3263
DOI	10.1021/jo802818s
文献子类	Article
英文摘要	We developed an efficient and convenient method for preparing N-substituted 2H- 1,4-benzoxazin-3-(4H)-ones from 2-halophenols via a nucleophilic substitution with 2-chloroacetamides followed by a Cul-catalyzed coupling cyclization. A broad spectrum of substrates can be effectively employed to afford the desired products in good yields. Since this method involves simple reaction conditions, a short reaction time, and a broad substrate scope, it is particularly attractive for the efficient preparation of biologically and medicinally interesting molecules.
资助项目	National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; international collaboration projects[2007DFB30370/20061334] ; International Collaboration Projects[20720102040] ; 863 Hi-Tech Program of China[2006AA020602]
WOS关键词	N-SUBSTITUTED 1,3-DIHYDROBENZIMIDAZOL-2-ONES ; NITROGEN-HETEROCYCLES ; SMILES REARRANGEMENT ; EFFICIENT ; DERIVATIVES ; ARYLATION ; SCAFFOLDS ; AMINES ; C-1027
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000264627400029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279267]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Liu, Hong
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Drug Discovery & Design, State Key Lab Drug Res,Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
推荐引用方式 GB/T 7714	Feng, Enguang,Huang, He,Zhou, Yu,et al. Copper(I)-Catalyzed One-Pot Synthesis of 2H-1,4-Benzoxazin-3-(4H)-ones from o-Halophenols and 2-Chloroacetamides[J]. JOURNAL OF ORGANIC CHEMISTRY,2009,74(7):2846-2849.
APA	Feng, Enguang,Huang, He,Zhou, Yu,Ye, Deju,Jiang, Hualiang,&Liu, Hong.(2009).Copper(I)-Catalyzed One-Pot Synthesis of 2H-1,4-Benzoxazin-3-(4H)-ones from o-Halophenols and 2-Chloroacetamides.JOURNAL OF ORGANIC CHEMISTRY,74(7),2846-2849.
MLA	Feng, Enguang,et al."Copper(I)-Catalyzed One-Pot Synthesis of 2H-1,4-Benzoxazin-3-(4H)-ones from o-Halophenols and 2-Chloroacetamides".JOURNAL OF ORGANIC CHEMISTRY 74.7(2009):2846-2849.