Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes

doi:10.1016/j.bmcl.2010.04.120

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	Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes
	Cho, Tang Peng 2; Long, Yang Fang 2; Gang, Lin Zhi 2; Yang, Wang 2; Jun, Lu He 2; Yuan, Shen Guang 2; Hong, Fu Jian 2; Lin, Wang 2; Liang, Guan Dong 2; Lei, Zhang 2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2010-06-15
卷号	20 期号:12 页码:3565-3568
关键词	Azobicyclo[3.3.0]octane derivatives Dipeptidyl peptidase 4 Oral glucose tolerance test Type 2 diabetes mellitus
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2010.04.120
文献子类	Article
英文摘要	A series of novel azobicyclo[3.3.0]octane derivatives were synthesized and evaluated as dipeptidyl peptidase 4 (DPP-4) inhibitors. The effort resulted in the discovery of inhibitor 2a, which exhibited excellent efficacies in an oral glucose tolerance test. Introduction of methyl group (2j) could prolong the inhibition of serum DPP-4 activity. (C) 2010 Elsevier Ltd. All rights reserved.
WOS关键词	DPP-IV INHIBITORS ; ANTIHYPERGLYCEMIC PROPERTIES ; POTENT ; GLP-1 ; SAXAGLIPTIN ; CONVERSION
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000278208200024
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278871]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Cho, Tang Peng
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Hengrui Pharmaceut Co Ltd, Shanghai 200245, Peoples R China;
推荐引用方式 GB/T 7714	Cho, Tang Peng,Long, Yang Fang,Gang, Lin Zhi,et al. Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(12):3565-3568.
APA	Cho, Tang Peng.,Long, Yang Fang.,Gang, Lin Zhi.,Yang, Wang.,Jun, Lu He.,...&Tai, Mong Xian.(2010).Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(12),3565-3568.
MLA	Cho, Tang Peng,et al."Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.12(2010):3565-3568.