Total Synthesis of Lamellarins D, H, and R and Ningalin B

doi:10.1021/ol1027877

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 新药研究国家重点实验室

	Total Synthesis of Lamellarins D, H, and R and Ningalin B
	Li, Qingjiang 1; Jiang, Jingqian 1; Fan, Aili 1; Cui, Yuxin 1; Jia, Yanxing 1,2
刊名	ORGANIC LETTERS
	2011-01-21
卷号	13 期号:2 页码:312-315
ISSN号	1523-7060
DOI	10.1021/ol1027877
文献子类	Article
英文摘要	A concise total synthesis of lamellarins D (7 steps), H (7 steps), and R (5 steps) and ningalin B (5 steps) is achieved starting from the corresponding aldehydes and amines. The synthesis features three oxidative reactions as key steps in a biomimetic manner, involving an AgOAc-mediated oxidative coupling reaction to construct the pyrrole core, a Pb(OAc)(4)-induced oxidative cyclization to form the lactone, and Kita's oxidation reaction to form the pyrrole-arene C-C bond.
资助项目	National Basic Research Program of China (973 Program)[2010CB833200] ; State Key Laboratory of Drug Research[00000000] ; National Natural Science Foundation of China[20972007] ; National Natural Science Foundation of China[20802005] ; National Natural Science Foundation of China[30930109] ; NCET[00000000]
WOS关键词	G TRIMETHYL ETHER ; HYPERVALENT IODINE(III) REAGENT ; IMINIUM SALT DERIVATIVES ; BIARYL COUPLING REACTION ; MARINE NATURAL-PRODUCTS ; EFFICIENT SYNTHESIS ; ALPHA 20-SULFATE ; LUKIANOL-A ; ALKALOIDS ; PYRROLES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000286130000036
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278621]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Jia, Yanxing
作者单位	1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Media, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Qingjiang,Jiang, Jingqian,Fan, Aili,et al. Total Synthesis of Lamellarins D, H, and R and Ningalin B[J]. ORGANIC LETTERS,2011,13(2):312-315.
APA	Li, Qingjiang,Jiang, Jingqian,Fan, Aili,Cui, Yuxin,&Jia, Yanxing.(2011).Total Synthesis of Lamellarins D, H, and R and Ningalin B.ORGANIC LETTERS,13(2),312-315.
MLA	Li, Qingjiang,et al."Total Synthesis of Lamellarins D, H, and R and Ningalin B".ORGANIC LETTERS 13.2(2011):312-315.