Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus alba

doi:10.1016/j.tet.2012.05.017

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	Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus alba
	Chen, Hua-Dong 1; Ding, Yuan-Qing 2,3; Yang, Sheng-Ping 1; Li, Xing-Cong 2,3; Wang, Xu-Jie 1; Zhang, Hai-Yan1 ; Ferreira, Daneel 2,3; Yue, Jian-Min1
刊名	TETRAHEDRON
	2012-07-29
卷号	68 期号:30 页码:6054-6058
关键词	Morus alba Natural products Morusalbanol A Absolute configuration Neuro-protective activity
ISSN号	0040-4020
DOI	10.1016/j.tet.2012.05.017
文献子类	Article
英文摘要	Morusalbanol A (1), a neuro-protective Diels Alder adduct with a new carbon skeleton, was isolated from the bark of Morus alba. Compound 1 showed evidence of interesting astropisomerism, and resulted in the absence of a number of key proton and carbon signals in the NMR spectra. Its structure was thus elucidated by spectroscopic analysis of its peracetylated derivative (2) and its absolute configuration established as 1S,3S,4R,55 via experimental and calculated ECD spectra of 1. In a neuro-protective assay, morusalbanol A (1) significantly attenuated the H2O2-induced cell damage in a dose-dependent manner. (C) 2012 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of the People's Republic of China[81021062] ; National Natural Science Foundation of the People's Republic of China[20932007] ; USDA Agricultural Research Service[58-6408-2-0009]
WOS关键词	ELECTRONIC CIRCULAR-DICHROISM ; THEORETICAL CALCULATION ; MORACEOUS PLANTS ; FLAVONOIDS ; BIOSYNTHESIS ; CHEMISTRY
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000306042000011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278010]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yue, Jian-Min
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA 3.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA;
推荐引用方式 GB/T 7714	Chen, Hua-Dong,Ding, Yuan-Qing,Yang, Sheng-Ping,et al. Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus alba[J]. TETRAHEDRON,2012,68(30):6054-6058.
APA	Chen, Hua-Dong.,Ding, Yuan-Qing.,Yang, Sheng-Ping.,Li, Xing-Cong.,Wang, Xu-Jie.,...&Yue, Jian-Min.(2012).Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus alba.TETRAHEDRON,68(30),6054-6058.
MLA	Chen, Hua-Dong,et al."Morusalbanol A, a neuro-protective Diels-Alder adduct with an unprecedented architecture from Morus alba".TETRAHEDRON 68.30(2012):6054-6058.