Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma

doi:10.3233/ACP-130084

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 新药研究国家重点实验室

	Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma
	Wang, Lin 3,4; Huang, Juxiang 3; Jiang, Minghu 5; Diao, Haizhen 3; Zhou, Huilei 3; Li, Xiaohe 3; Chen, Qingchun 3; Jiang, Zhenfu 1; Feng, Haitao 6; Wolfl, Stefan 2
刊名	ANALYTICAL CELLULAR PATHOLOGY
	2013
卷号	36 期号:3-4 页码:93-105
关键词	Cartilage oligomeric matrix protein (COMP) cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma
ISSN号	2210-7177
DOI	10.3233/ACP-130084
文献子类	Article
英文摘要	BACKGROUND: To understand cartilage oligomeric matrix protein (COMP) mechanism network from human normal adjacent tissues to lung adenocarcinoma. METHODS: COMP complete different activated (all no positive correlation, Pearson CC < 0.25) and uncomplete (partly no positive correlation except COMP, Pearson CC< 0.25) network were identified in higher lung adenocarcinoma compared with lower human normal adjacent tissues from the corresponding COMP-stimulated (>= 0.25) or inhibited (Pearson CC <= -0.25) overlapping molecules of Pearson correlation coefficient (CC) and GRNInfer, respectively. COMP complete different activated and inhibited (all no positive correlation, Pearson CC< 0.25) mechanisms networks of higher lung adenocarcinoma and lower human normal adjacent tissues were constructed by integration of Pearson CC, GRNInfer and GO. As visualized by integration of GO, KEGG, GenMAPP, BioCarta and Disease, we deduced COMP complete different activated and inhibited network in higher lung adenocarcinoma and lower human normal adjacent tissues. RESULTS: As visualized by GO, KEGG, GenMAPP, BioCarta and disease database integration, we proposed mainly that the mechanism and function of COMP complete different activated network in higher lung adenocarcinoma was involved in COMP activation with matrix-localized insulin-like factor coupling carboxypeptidase to metallopeptidase-induced proteolysis, whereas the corresponding inhibited network in lower human normal adjacent tissues participated in COMP inhibition with nucleus-localized vasculogenesis, B and T cell differentiation and neural endocrine factors coupling pyrophosphatase-mediated proteolysis. However, COMP complete different inhibited network in higher lung adenocarcinoma included COMP inhibition with nucleus-localized chromatin maintenance, licensing and assembly factors coupling phosphatase-inhibitor to cytokinesis regulators-mediated cell differentiation, whereas the corresponding activated network in lower human normal adjacent tissues contained COMP activation with cytolplasm-localized translation elongation factor coupling fucosyltransferase to ubiquitin-protein ligase-induced cell differentiation. CONCLUSION: COMP different networks were verified not only by complete and uncomplete COMP activated or inhibited networks within human normal adjacent tissues or lung adenocarcinoma, but also by COMP activated and inhibited network between human normal adjacent tissues and lung adenocarcinoma.
资助项目	National Natural Science Foundation of China[61171114] ; State Key Laboratory of Drug Research[SIMM1302KF] ; Automatical Scientific Planning of Tsinghua University[20111081023] ; Automatical Scientific Planning of Tsinghua University[20111081010] ; State Key Lab of Pattern Recognition Open Foundation[00000000]
WOS关键词	SYSTEMS-THEORETICAL ANALYSIS ; CYCLE COMPUTATIONAL NETWORK ; HEPATOCELLULAR-CARCINOMA ; GROWTH-PLATE ; COMP ; COLLAGEN ; PSEUDOACHONDROPLASIA ; HEPATITIS/CIRRHOSIS ; TRANSFORMATION ; CONSTRUCTION
WOS研究方向	Oncology ; Cell Biology ; Pathology
语种	英语
出版者	IOS PRESS
WOS记录号	WOS:000326749200004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277784]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Wang, Lin
作者单位	1.China Univ Min & Technol, Sch Mech Elect & Informat Engn, Beijing, Peoples R China; 2.Heidelberg Univ, Inst Pharm & Mol Biotechnol, Heidelberg, Germany 3.Beijing Univ Posts & Telecommun, Sch Elect Engn, Bioinformat Ctr, Beijing 100876, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China; 5.Tsinghua Univ, Sch Humanities & Social Sci, Lab Computat Linguist, Beijing 100084, Peoples R China; 6.Heilongjiang Univ Chinese Med, Dean Dept, Harbin, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Lin,Huang, Juxiang,Jiang, Minghu,et al. Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma[J]. ANALYTICAL CELLULAR PATHOLOGY,2013,36(3-4):93-105.
APA	Wang, Lin.,Huang, Juxiang.,Jiang, Minghu.,Diao, Haizhen.,Zhou, Huilei.,...&Wolfl, Stefan.(2013).Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma.ANALYTICAL CELLULAR PATHOLOGY,36(3-4),93-105.
MLA	Wang, Lin,et al."Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma".ANALYTICAL CELLULAR PATHOLOGY 36.3-4(2013):93-105.