A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo [2,1-f][1,2,4] triazin-4(3H)-ones

doi:10.1016/j.tet.2013.02.004

	A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo [2,1-f][1,2,4] triazin-4(3H)-ones
	Chen, Yanhong; Xiang, Haoyue; Tan, Cun; Xie, Yuyuan; Yang, Chunhao
刊名	TETRAHEDRON
	2013-04-01
卷号	69 期号:13 页码:2714-2719
关键词	Tandem annulation Cupric chloride 1-Amino-1H-pyrrole-2-amides Privileged structure Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones
ISSN号	0040-4020
DOI	10.1016/j.tet.2013.02.004
文献子类	Article
英文摘要	An efficient tandem method for the annulation of 1-amino-1H-pyrrole-2-amides with various substituted benzaldehydes, heteroaryl aldehydes, alkyl aldehydes or even acetals, promoted by cupric chloride, to synthesize 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones is reported. This approach provides a useful method for constructing the privileged structure in medicinal chemistry. Electron-donating groups on both partners could accelerate the reaction. (C) 2013 Elsevier Ltd. All rights reserved.
资助项目	Ministry of Science and Technology of China (National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program')[2012ZX09301001-001] ; Chinese Academy of Sciences (Interdisciplinary Cooperation Team' Program for Science and Technology Innovation)[00000000] ; National Natural Science Foundation of China[20772138] ; National Natural Science Foundation of China[90713034] ; SKLDR/SIMM[SIMM1105KF-02]
WOS关键词	KINASE INHIBITOR ; DISCOVERY ; OXIDANT ; DMSO
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000315843800005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277684]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yang, Chunhao
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, SIBS, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yanhong,Xiang, Haoyue,Tan, Cun,et al. A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo [2,1-f][1,2,4] triazin-4(3H)-ones[J]. TETRAHEDRON,2013,69(13):2714-2719.
APA	Chen, Yanhong,Xiang, Haoyue,Tan, Cun,Xie, Yuyuan,&Yang, Chunhao.(2013).A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo [2,1-f][1,2,4] triazin-4(3H)-ones.TETRAHEDRON,69(13),2714-2719.
MLA	Chen, Yanhong,et al."A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo [2,1-f][1,2,4] triazin-4(3H)-ones".TETRAHEDRON 69.13(2013):2714-2719.