Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines

doi:10.1021/jo500176g

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	Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines
	Qiu, Lin 1; Gao, Lixin 2; Tang, Jixing 1; Wang, Dongwei 1; Guo, Xin 1; Liu, Shunying 1; Yang, Liping 1; Li, Jia1,2 ; Hu, Wenhao 1
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2014-05-02
卷号	79 期号:9 页码:4142-4147
ISSN号	0022-3263
DOI	10.1021/jo500176g
文献子类	Article
英文摘要	A first example of 1,4-conjugate addition of beta,gamma-unsaturated N-sulfonylimines via the oxonium ylides trapping process was developed. This method afforded a novel and efficient access for the high regio- and diastereoselective construction of alpha-hydroxyl-delta-amino esters derivatives, which exhibit inhibitory activity on PTP1B and SIRT1 enzymes in vitro. The synthetic potentials and the biological activity of the resulting products were well demonstrated to be promising for drug discovery.
资助项目	Specialized Research Fund for the Doctoral Program of Higher Education[20100076110005]
WOS关键词	DIELS-ALDER REACTION ; ENANTIOSELECTIVE 3-COMPONENT REACTIONS ; CHIRAL BRONSTED ACID-RH-2(OAC)(4) ; ASYMMETRIC CONJUGATE ADDITION ; ALCOHOLIC OXONIUM YLIDE ; ALPHA,BETA-UNSATURATED IMINES ; MULTICOMPONENT REACTIONS ; 1,3-DICARBONYL COMPOUNDS ; COOPERATIVE CATALYSIS ; DIALKYLZINC REAGENTS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000335490700045
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277083]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心
通讯作者	Liu, Shunying
作者单位	1.E China Normal Univ, Dept Chem, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Qiu, Lin,Gao, Lixin,Tang, Jixing,et al. Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines[J]. JOURNAL OF ORGANIC CHEMISTRY,2014,79(9):4142-4147.
APA	Qiu, Lin.,Gao, Lixin.,Tang, Jixing.,Wang, Dongwei.,Guo, Xin.,...&Hu, Wenhao.(2014).Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines.JOURNAL OF ORGANIC CHEMISTRY,79(9),4142-4147.
MLA	Qiu, Lin,et al."Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines".JOURNAL OF ORGANIC CHEMISTRY 79.9(2014):4142-4147.