Prenylated Indole Diketopiperazines from the Marine-Derived Fungus Aspergillus versicolor

doi:10.1021/jo5010179

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Prenylated Indole Diketopiperazines from the Marine-Derived Fungus Aspergillus versicolor
	Peng, Jixing 1; Gao, Huquan 1; Li, Jing1 ; Ai, Jing2 ; Geng, Meiyu2 ; Zhang, Guojian 1; Zhu, Tianjiao 1; Gu, Qianqun 1; Li, Dehai 1
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2014-09-05
卷号	79 期号:17 页码:7895-7904
ISSN号	0022-3263
DOI	10.1021/jo5010179
文献子类	Article
英文摘要	Seven new prenylated indole diketopiperazines, versicamides A-G (1-7) and a novel chemical derivative from 7, versicamide H (8), along with three known analogic diketopiperazines (9-11) were obtained from the marine-derived fungus Aspergillus versicolor HDN08-60. Their structures were determined by spectroscopic techniques, including 2D NMR, ECD calculations, and single-crystal X-ray diffraction analysis, together with the assistance of further chemical conversions. The cytotoxicities of 1-8 were tested against the HeLa, HCT-116, HL-60, and K562 cell lines, but only 8 exhibited moderate activity against HL-60 cells, with an IC50 value of 8.7 mu M. Further investigation with target screening showed that 8 exhibited selective PTK inhibitory activities.
资助项目	National Natural Science Foundation of China[41176120] ; National Natural Science Foundation of China[21372208] ; National High Technology Research and Development Program of China[2013AA092901] ; NSFC-Shandong Joint Fund[U1406402] ; Program for New Century Excellent Talents in University[NCET-12-0499] ; State Oceanic Administration[2010418022-3] ; Program for Changjiang Scholars and Innovative Research Team in University[IRT0944]
WOS关键词	PENICILLIUM SP ; EFFUSES H1-1 ; ALKALOIDS ; VARIECOLOR ; PRECURSOR ; ASSAY
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000341345400012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276909]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Li, Dehai
作者单位	1.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Peng, Jixing,Gao, Huquan,Li, Jing,et al. Prenylated Indole Diketopiperazines from the Marine-Derived Fungus Aspergillus versicolor[J]. JOURNAL OF ORGANIC CHEMISTRY,2014,79(17):7895-7904.
APA	Peng, Jixing.,Gao, Huquan.,Li, Jing.,Ai, Jing.,Geng, Meiyu.,...&Li, Dehai.(2014).Prenylated Indole Diketopiperazines from the Marine-Derived Fungus Aspergillus versicolor.JOURNAL OF ORGANIC CHEMISTRY,79(17),7895-7904.
MLA	Peng, Jixing,et al."Prenylated Indole Diketopiperazines from the Marine-Derived Fungus Aspergillus versicolor".JOURNAL OF ORGANIC CHEMISTRY 79.17(2014):7895-7904.