pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer

doi:10.1002/adfm.201404484

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer
	Yu, Haijun2,3 ; Cui, Zhirui 2,3,4; Yu, Pengcheng 1,2,3; Guo, Chengyue 2,3; Feng, Bing 2,3; Jiang, Tongying 4; Wang, Siling 4; Yin, Qi2,3 ; Zhong, Dafang2,5 ; Yang, Xiangliang 1
刊名	ADVANCED FUNCTIONAL MATERIALS
	2015-05-06
卷号	25 期号:17 页码:2489-2500
ISSN号	1616-301X
DOI	10.1002/adfm.201404484
文献子类	Article
英文摘要	The acquisition of multidrug resistance (MDR) is a major hurdle for the successful chemotherapy of tumors. Herein, a novel hybrid micelle with pH and near-infrared (NIR) light dual-responsive property is reported for reversing doxorubicin (DOX) resistance in breast cancer. The hybrid micelles are designed to integrate the pH-and NIR light-responsive property of an amphiphilic diblock polymer and the high DOX loading capacity of a polymeric prodrug into one single nanocomposite. At physiological condition (i.e., pH 7.4), the micelles form compact nanostructure with particle size around 30 nm to facilitate blood circulation and passive tumor targeting. Meanwhile, the micelles are quickly dissociated in weakly acidic environment (i.e., pH <= 6.2) to release DOX prodrug. When exposed to NIR laser irradiation, the hybrid micelles can trigger notable tumor penetration and cytosol release of DOX payload by inducing tunable hyperthermia effect. In combination with localized NIR laser irradiation, the hybrid micelles significantly inhibit the growth of DOX-resistant MCF-7/ADR breast cancer in an orthotopic tumor bearing mouse model. Taken together, this pH and NIR light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release can be an effective nanoplatform to combat cancer MDR.
资助项目	National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2012CB932502] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; SA-SIBS Scholarship Program[00000000]
WOS关键词	MULTIDRUG-RESISTANCE ; CO-DELIVERY ; LUNG-CANCER ; NANOPARTICLES ; CELLS ; SIRNA ; CHEMOTHERAPY ; THERAPY ; THERAPEUTICS ; ACCUMULATION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000354200000001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276535]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yu, Haijun
作者单位	1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yu, Haijun,Cui, Zhirui,Yu, Pengcheng,et al. pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(17):2489-2500.
APA	Yu, Haijun.,Cui, Zhirui.,Yu, Pengcheng.,Guo, Chengyue.,Feng, Bing.,...&Li, Yaping.(2015).pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,25(17),2489-2500.
MLA	Yu, Haijun,et al."pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 25.17(2015):2489-2500.