Limonoids with Anti-HIV Activity from Cipadessa cinerascens

doi:10.1021/acs.jnatprod.5b00025

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	Limonoids with Anti-HIV Activity from Cipadessa cinerascens
	Yu, Jin-Hai 1; Wang, Guo-Cai 1; Han, Ying-Shan 2; Wu, Yan 1; Wainberg, Mark A.2; Yue, Jian-Min1
刊名	JOURNAL OF NATURAL PRODUCTS
	2015-06
卷号	78 期号:6 页码:1243-1252
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.5b00025
文献子类	Article
英文摘要	Sixteen new limonoids, named ciparasins A-P (1-16), comprising three Structural categories of trijugin-type (1-7), cipadesin-type and prieurianin-type (16) compounds, as well as 15 known limonoid analogues (17-31), were isolated from Cipadessa cinerascens. Ciparasins E-G (5-7) were found to possess a rare gamma-hydroxylbutenolide moiety at C-17. Ciparasins 13 (2) and P (16) showed significant anti-HIV activities, with EC50 values of 5.5 +/- 0.6 (Si >7.2) and 6.1 +/- 0.7 (SI > 6.5) mu M, respectively.
资助项目	National Natural Science Foundation[81273398] ; Ministry of Science and Technology of the People's Republic of China[2012CB721105]
WOS关键词	TRIJUGIN-TYPE LIMONOIDS ; BACCIFERA ; LEAVES ; TETRANORTRITERPENOIDS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000357138300008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276502]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yue, Jian-Min
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.McGill Univ, Jewish Gen Hosp, AIDS Ctr, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada
推荐引用方式 GB/T 7714	Yu, Jin-Hai,Wang, Guo-Cai,Han, Ying-Shan,et al. Limonoids with Anti-HIV Activity from Cipadessa cinerascens[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(6):1243-1252.
APA	Yu, Jin-Hai,Wang, Guo-Cai,Han, Ying-Shan,Wu, Yan,Wainberg, Mark A.,&Yue, Jian-Min.(2015).Limonoids with Anti-HIV Activity from Cipadessa cinerascens.JOURNAL OF NATURAL PRODUCTS,78(6),1243-1252.
MLA	Yu, Jin-Hai,et al."Limonoids with Anti-HIV Activity from Cipadessa cinerascens".JOURNAL OF NATURAL PRODUCTS 78.6(2015):1243-1252.