Quick Serological Detection of a Cancer Biomarker with an Agglutinated Supramolecular Glycoprobe

doi:10.1021/acs.analchem.5b02384

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	Quick Serological Detection of a Cancer Biomarker with an Agglutinated Supramolecular Glycoprobe
	He, Xiao-Peng 2,3; Hu, Xi-Le 2,3; Jin, Hong-Ying 2,3; Gan, Jiemin 4; Zhu, Huili 4; Li, Jia1 ; Long, Yi-Tao 2,3; Tiant, He 2,3
刊名	ANALYTICAL CHEMISTRY
	2015-09-01
卷号	87 期号:17 页码:9078-9083
ISSN号	0003-2700
DOI	10.1021/acs.analchem.5b02384
文献子类	Article
英文摘要	While serology represents the forefront technique for cancer diagnosis, current clinical methods for the detection of serum biomarkers have flaws in terms of the need of complicated manipulations, long analytical time, and high cost. Here, we develop a supramolecular glycoprobe for the quick serological detection of a cancer biomarker. The probe formed by agglutination between self-assembled glyco-gold nanoparticles and a lectin shows subtle optical variations upon the competitive recognition of a glycoprotein biomarker secreted by cancer cells, tumor-bearing mice, as well as clinical cancer patients, with no response to a series of controls including the serum of hepatitis patients. This research provides an insight into the development of effective tools for serological diagnosis of cancer.
资助项目	973 project[2013CB733700] ; National Natural Science Foundation of China[21176076] ; Shanghai Science and Technology Commission[13NM1400900] ; Fundamental Research Funds for Central Universities[222201414010]
WOS关键词	HEPATOCELLULAR-CARCINOMA ; GOLD NANOPARTICLES ; INFLUENZA-VIRUS ; LUNG-CANCER ; IN-VIVO ; GLYCONANOPARTICLES ; HETEROGENEITY ; PROTEINS ; SURVIVAL ; TIME
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000360773100066
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276412]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心
通讯作者	Zhu, Huili
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 3.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; 4.Fudan Univ, Huadong Hosp, Shanghai 200040, Peoples R China
推荐引用方式 GB/T 7714	He, Xiao-Peng,Hu, Xi-Le,Jin, Hong-Ying,et al. Quick Serological Detection of a Cancer Biomarker with an Agglutinated Supramolecular Glycoprobe[J]. ANALYTICAL CHEMISTRY,2015,87(17):9078-9083.
APA	He, Xiao-Peng.,Hu, Xi-Le.,Jin, Hong-Ying.,Gan, Jiemin.,Zhu, Huili.,...&Tiant, He.(2015).Quick Serological Detection of a Cancer Biomarker with an Agglutinated Supramolecular Glycoprobe.ANALYTICAL CHEMISTRY,87(17),9078-9083.
MLA	He, Xiao-Peng,et al."Quick Serological Detection of a Cancer Biomarker with an Agglutinated Supramolecular Glycoprobe".ANALYTICAL CHEMISTRY 87.17(2015):9078-9083.