Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities

doi:10.1016/j.ejmech.2015.08.035

	Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities
	Liu, Gang 2,3; Song, Shanshan 1; Shu, Shiqi 4; Miao, Zehong 1; Zhang, Ao2,3 ; Ding, Chunyong2,3
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2015-10-20
卷号	103 页码:17-28
关键词	Artemisinin Spirobicyclic artemalogues 1,3-dipolar cycloaddition Stereoconfiguration Antiprolifereative effect
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2015.08.035
文献子类	Article
英文摘要	The sesquiterpene lactone framework of artemisinin was used as a drug repositioning prototype for the development of novel antitumor drugs. Several series of novel artemisinin analogues (artemalogues) were designed and synthesized through 1,3-dipolar cycloaddition of artemisitene with nitrile oxides or nitrones. The isoxazolidine-containing spirobicyclic artemalogue 11b turns out to be the most potent with low micromolar IC50 values against all three tumor cells, which were at least 4- to 14-fold more potent than the parent artemisinin. (C) 2015 Elsevier Masson SAS. All rights reserved.
资助项目	Pujiang Talent Project from Shanghai Commission of Science and Technology[14PJ1410700] ; Chinese NSF[81402790] ; Chinese NSF[81125021] ; Chinese NSF[81373277] ; Chinese NSF[81430080] ; National Program on Key Basic Research Project of China[2015CB910603-004]
WOS关键词	LEUKEMIA-CELLS ; PLASMODIUM-FALCIPARUM ; ANTIMALARIAL ACTIVITY ; CANCER-CELLS ; DERIVATIVES ; CYTOTOXICITY ; HEME ; DIMERS ; AGENTS ; MOLECULES
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000363344700002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276356]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Ding, Chunyong
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med SIMM, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Synthet Organ & Med Chem Lab, Shanghai Inst Mat Med SIMM, Shanghai 201203, Peoples R China; 4.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Liu, Gang,Song, Shanshan,Shu, Shiqi,et al. Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2015,103:17-28.
APA	Liu, Gang,Song, Shanshan,Shu, Shiqi,Miao, Zehong,Zhang, Ao,&Ding, Chunyong.(2015).Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,103,17-28.
MLA	Liu, Gang,et al."Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 103(2015):17-28.